Anticoagulation Overdose When Receiving Vitamin K Antagonists Combined with Coenzyme Q10: Review of the World's Medicine

Coagulation disorders in patients receiving vitamin K antagonist anticoagulants (VKAs) when treating patients with cardiovascular diseases that cause blood clots. The world has had several studies on the effects of the somes combined supplementations to have coagulation disorders as well as bleeding complications, but there are still many angles that need further research, especially the effects of the Coenzyme Q10 supplementation. Study on 3 cases of mechanical artificial heart valve surgery, atrial fibrillation, heart failure who were receiving anticoagulant therapy by VKAs drugs and had use of the Coenzyme Q10 supplements that can cause anticoagulation overdose. Clinical cases were found to have hemorrhagic bleeding with a high International Normalized Index (INR) and they were acutely managed with timely resuscitation and return the coagulation index to normal. It is recommended that patients who are receiving vitamin K antagonist anticoagulants should not take with the Coenzyme Q10 supplements to avoid possible coagulation disorders or bleeding may happen.