罗舒伐他汀和氨氯地平在高血压、高胆固醇血症患者中的自由或固定联合治疗目标和治疗依从性ROSA RARA:一项由意大利门诊心脏病专家自发进行的观察性研究

R. Del Pinto, G. Baldini, C. Ferri, G. Zito
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引用次数: 0

摘要

背景:高血压和低密度脂蛋白高胆固醇血症经常共存,有效治疗对心血管健康有积极意义。我们的目的是确定氨氯地平和瑞舒伐他汀作为自由或固定组合对高血压患者伴低密度脂蛋白高胆固醇血症的血压(BP)和低密度脂蛋白胆固醇的影响,以及治疗满意度。方法:在意大利心脏病门诊进行了一项自发的纵向观察研究。符合条件的个体(年龄≥18岁,知情同意,除RAAS抑制剂外稳定使用5或10 mg氨氯地平治疗,稳定使用10或20 mg瑞舒伐他汀治疗)在12周和24周时接受家庭和办公室血压和ldl -胆固醇评估。评估血压和低密度脂蛋白胆固醇控制率及对固定组合的满意度。结果:285名受试者入组(51%M;67±10y;94对自由组合)。12周时,两组患者的平均血压和低密度脂蛋白胆固醇均降低,固定联合组高血压控制率较高;在24周时,与基线相比,它们进一步降低,固定组的家庭收缩压低于自由联合组(121.9±17.6 vs 129.4±8.5 mmHg;P = 0.03)。固定联合治疗的患者对该方案的满意度高于自由联合治疗。结论:钙通道阻滞剂与他汀类药物固定联合治疗在临床疗效和患者满意度方面具有优势。
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ROSuvastatin and Amlodipine as free or fixed combination on theRApeutic taRgets and treatment Adherence in hypertensive, hypercholesterolemic individuals. ROSA RARA: a spontaneous, observational study conducted by italian outpatient cardiologists
Background: Hypertension and LDL hypercholesterolemia often coexist, and their effective treatment has favorable implications for cardiovascular health. We aimed at defining the impact of amlodipine and rosuvastatin as free or fixed combinations on blood pressure (BP) and LDL-cholesterol, and the satisfaction with treatment, in hypertensive individuals with LDL hypercholesterolemia. Methods: A spontaneous longitudinal observational study was conducted at Italian cardiology outpatients clinics. Eligible individuals (age ≥ 18y, informed consent, stable 5 or 10 mg amlodipine therapy in addition to a RAAS inhibitor, stable 10 or 20 mg rosuvastatin therapy) underwent home and office BP and LDL-cholesterol assessment at 12 and 24 weeks. BP and LDL-cholesterol control rates and satisfaction with the fixed combination were assessed. Results: 285 participants were enrolled (51%M; 67 ± 10y; 94 on the free combination). At 12 weeks, mean BP and LDL-cholesterol were reduced in both groups, with higher hypertension control rates in the fixed combination group; at 24 weeks they were further reduced compared with baseline, and home systolic BP was lower in the fixed than the free combination group (121.9 ± 17.6 vs 129.4 ± 8.5 mmHg; p = 0.03). Patients in the fixed combination reported higher satisfaction with this regimen than with the free combination. Conclusions: The fixed combination of calcium channel blocker and statin appears to have advantages in terms of clinical efficacy and patients’ satisfaction.
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