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引用次数: 113

摘要

非必需的有毒重金属(D型重金属)的膜转运不仅控制它们进入细胞内靶位,而且有助于决定它们的吸收、分布和从体内排泄。膜在D类金属毒理学中的关键作用引起了许多研究者的注意,并且关于金属跨膜转移的机制已经收集了大量的信息。金属在不同细胞中,甚至在同一细胞的两侧,或在不同的生理条件下的运输特性是不相同的,也没有一个统一的假设来解释所有细胞中的这一过程。然而,针对不同细胞提出的机制似乎可能代表了一些共同主题的变化。
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Transport of toxic heavy metals across cell membranes.
Membrane transport of nonessential toxic heavy metals (type D heavy metals) not only controls their access to intracellular target sites but also helps determine their uptake, distribution, and excretion from the body. The critical role of membranes in the toxicology of class D metals has attracted the attention of many investigators, and extensive information has been collected on the mechanism(s) of metal transfer across membranes. Characteristics of metal transport in different cells, or even on opposite sides of the same cell, or under different physiological conditions, are not identical, and no unitary hypothesis has been formulated to explain this process in all cells. However, it seems possible that the mechanisms proposed for different cells represent variations on a few common themes.
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