A. Dabeer, Dinesh Kumar Mishra, N. Farooqui, Arpit Gawshinde
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引用次数: 1
摘要
近年来,口服给药系统的研究和开发取得了科技进步。本研究的目的是利用超快速崩解剂如交联棉糖钠制备非诺贝特直接压片并对其进行评价。利用强力崩解剂和赋形剂制备快速崩解剂是一种高效、商业可行的方法。在目前的研究中,水溶性差是药物最重要的参数之一,成功研制的非诺贝特口服制剂是采用溶剂蒸发法研制的药物:PEG 6000 In (1:5 w/w)。最佳处方为F7,其厚度、硬度、重量变化、脆度、药物含量、药物释放率等理化评价参数在15 min内均达到79.98%,且符合最大通口释放动力学,回归系数r2 = 0.995。
Formulation and Evaluation of Orodispersible Tablet of poorly water Soluble Drug ‘Fenofibrate’ by Using Solubility Enhancement Technique
In the recent years scientific and technological advancements have been made in the research and development of oral drug delivery systems. The aim of this study was to formulate and evaluate of orodispersible tablets by direct compression for fenofibrate by using super fast disintegrating agents like croscarmellose sodium. The use of super disintegrant and excipient for preparation of fast disintegrating is highly effective and commercially feasible. In the present investigation poorly water soluble drug is one of the most important parameters of oral formulations sucessfully developed fenofibrate was using solvent evaporation method drug: PEG 6000 in (1:5 w/w). The formulation F7 was the optimized formula that showed satisfactory results with various physicochemical evaluation parameters like thickness, hardness, weight variation, friability, drug content, % drug release almost 79.98% within 15 min. and it was follow the maximum higuchi release kinetics that regression coefficient values ‘r2’= 0.995.