靶向给药纳米海绵的合成与应用

Parag Raj Behura, T. Vamshikrishna
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引用次数: 0

摘要

纳米技术的出现和发展为靶向给药系统带来了新的概念。将一个分子靶向到一个特定的位置会带来一定的药理作用。纳米海绵是纳米技术的一部分,具有亲水性和亲脂性。它们是一种胶体载体,通过增强和改善药物在体内组织中的物理和化学稳定性以及提高药物的渗透性和生物利用度来改善难溶性药物的水溶性。纳米海绵是一种胶体大小和纳米腔大小的微小海绵。一般应用于口服给药,肠外给药,局部给药和水凝胶形式。本文综述了纳米海绵的各种合成方法及其应用。
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A Novel Revolutionary Approach of a Synthesis and Application of Targeted Nanosponge Drug Delivery
The novel and development of nanotechnology have brought a term targeted drug delivery system. Targeting a molecule to a specific site has brought a certain pharmacological action. Nanosponge is a part of nanotechnology which is both hydrophilic and lipophilic in nature. They are colloidal carriers which improve the aqueous solubility of the poorly soluble drug by enhancing and improving the physical and chemical stability and improving the permeability and bioavailability in the body tissues. Nanosponge are tiny sponges which are in the size of colloidal sizes and nanosized cavity. There general application can be seen in oral administration, parenteral administration, topical administration and available in the form of hydrogel. The current review discussion various methods of synthesis and application of nanosponges.
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