{"title":"结构多样的含吡嗪环抗结核分子的研制","authors":"M. Asif, Anita Singh, Lakshmayya","doi":"10.4103/2229-5186.108796","DOIUrl":null,"url":null,"abstract":"There has been considerable interest in the development of new molecule with antibacterial activities particularly against tuberculosis because mycobacterium species have developed resistance against currently used drugs, their toxic effect, and longer duration of therapy. The pyridazine derivatives are an important class of compound for new drugs research and development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their antitubercular activity. These observations have been guiding in the development of new molecules that possess potent antitubercular activity with minimum side effects or effective against multidrug-resistant, extensively drug-resistant mycobacterium strains, and also in patient co-infected with HIV/AIDS.","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":"14 1","pages":"1"},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"13","resultStr":"{\"title\":\"Development of structurally diverse antitubercular molecules with pyridazine ring\",\"authors\":\"M. Asif, Anita Singh, Lakshmayya\",\"doi\":\"10.4103/2229-5186.108796\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"There has been considerable interest in the development of new molecule with antibacterial activities particularly against tuberculosis because mycobacterium species have developed resistance against currently used drugs, their toxic effect, and longer duration of therapy. The pyridazine derivatives are an important class of compound for new drugs research and development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their antitubercular activity. These observations have been guiding in the development of new molecules that possess potent antitubercular activity with minimum side effects or effective against multidrug-resistant, extensively drug-resistant mycobacterium strains, and also in patient co-infected with HIV/AIDS.\",\"PeriodicalId\":10187,\"journal\":{\"name\":\"Chronicles of Young Scientists\",\"volume\":\"14 1\",\"pages\":\"1\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chronicles of Young Scientists\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/2229-5186.108796\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chronicles of Young Scientists","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/2229-5186.108796","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Development of structurally diverse antitubercular molecules with pyridazine ring
There has been considerable interest in the development of new molecule with antibacterial activities particularly against tuberculosis because mycobacterium species have developed resistance against currently used drugs, their toxic effect, and longer duration of therapy. The pyridazine derivatives are an important class of compound for new drugs research and development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their antitubercular activity. These observations have been guiding in the development of new molecules that possess potent antitubercular activity with minimum side effects or effective against multidrug-resistant, extensively drug-resistant mycobacterium strains, and also in patient co-infected with HIV/AIDS.