{"title":"暴露于n-亚硝胺的受试者的胃幽门螺杆菌粘膜活检中p62~(泛myc)的表达增加","authors":"D. Daju","doi":"10.1097/00008469-199609001-00042","DOIUrl":null,"url":null,"abstract":"To elucidate the possible role of myc oncogene in human gastric carcinogenesis byN-nitrosamides Methods: Expression of pan-myc in gastric biopsies of pylori and concentration of totalN-nitrosamides in fasting gastric juice samples were studied simultaneously with immunochemohistological method and liquid mobile-photohydrolysis-pyrolysis energy analyzer. Results: Ofgastric juice samples, 57. 1 % were N-nitrosamide-detectable. Evaluation of p62pan-myc in mucosal epithelial cells Was found in 6 gastric biopsies. All the 6 p62pan-myc-positive biopsies were from patients whosegastric juices were N-nitrosamide-detectable, whereas no p62 pan-myc-positive biopsy was found inthose from 15 cases whose gastric juices were N-nitrosamide-undetectab1e (P= 0. 0239). Such relationwas not observed for p21pan-ras, p185c-erbB-2, and p53mutant p53. Conclusion: These results indicate firstlythat expression of myc oncogene correlated with the exposure to N-nitrosamides in human stomach positively and myc oncogene may play a role in the early stage of human gastric carcinogenesis by N-nitrosamides.","PeriodicalId":22576,"journal":{"name":"The Journal of Beijing Medical University","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"INCREASED EXPRESSION OF p62~(pan-myc) IN GASTRIC PYLORI MUCOSA BIOPSIES FROM SUBJECTS EXPOSED TO N-NITROSAMIDES\",\"authors\":\"D. Daju\",\"doi\":\"10.1097/00008469-199609001-00042\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"To elucidate the possible role of myc oncogene in human gastric carcinogenesis byN-nitrosamides Methods: Expression of pan-myc in gastric biopsies of pylori and concentration of totalN-nitrosamides in fasting gastric juice samples were studied simultaneously with immunochemohistological method and liquid mobile-photohydrolysis-pyrolysis energy analyzer. Results: Ofgastric juice samples, 57. 1 % were N-nitrosamide-detectable. Evaluation of p62pan-myc in mucosal epithelial cells Was found in 6 gastric biopsies. All the 6 p62pan-myc-positive biopsies were from patients whosegastric juices were N-nitrosamide-detectable, whereas no p62 pan-myc-positive biopsy was found inthose from 15 cases whose gastric juices were N-nitrosamide-undetectab1e (P= 0. 0239). Such relationwas not observed for p21pan-ras, p185c-erbB-2, and p53mutant p53. Conclusion: These results indicate firstlythat expression of myc oncogene correlated with the exposure to N-nitrosamides in human stomach positively and myc oncogene may play a role in the early stage of human gastric carcinogenesis by N-nitrosamides.\",\"PeriodicalId\":22576,\"journal\":{\"name\":\"The Journal of Beijing Medical University\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Beijing Medical University\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/00008469-199609001-00042\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Beijing Medical University","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/00008469-199609001-00042","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
INCREASED EXPRESSION OF p62~(pan-myc) IN GASTRIC PYLORI MUCOSA BIOPSIES FROM SUBJECTS EXPOSED TO N-NITROSAMIDES
To elucidate the possible role of myc oncogene in human gastric carcinogenesis byN-nitrosamides Methods: Expression of pan-myc in gastric biopsies of pylori and concentration of totalN-nitrosamides in fasting gastric juice samples were studied simultaneously with immunochemohistological method and liquid mobile-photohydrolysis-pyrolysis energy analyzer. Results: Ofgastric juice samples, 57. 1 % were N-nitrosamide-detectable. Evaluation of p62pan-myc in mucosal epithelial cells Was found in 6 gastric biopsies. All the 6 p62pan-myc-positive biopsies were from patients whosegastric juices were N-nitrosamide-detectable, whereas no p62 pan-myc-positive biopsy was found inthose from 15 cases whose gastric juices were N-nitrosamide-undetectab1e (P= 0. 0239). Such relationwas not observed for p21pan-ras, p185c-erbB-2, and p53mutant p53. Conclusion: These results indicate firstlythat expression of myc oncogene correlated with the exposure to N-nitrosamides in human stomach positively and myc oncogene may play a role in the early stage of human gastric carcinogenesis by N-nitrosamides.
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