有证据表明香叶醇会引起过敏性接触性皮炎吗?

J. Hostynek,, H. Maibach
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引用次数: 9

摘要

香精物质香叶醇被认为是过敏性接触性皮炎的常见原因。对文献的回顾表明,当分析潜在的临床和实验数据时,很少或很少建立明确的因果关系。鉴于该物质的致敏潜力普遍较弱,再加上其暴露条件普遍较低,预计临床病例的发生率不会特别高。这并不是说香叶醇是公众中IV型过敏的常见诱因。然而,这种过敏一旦建立,在文献中通常被认为是过敏性接触性皮炎的任何病例中,有多少次是由这种过敏引起的,还有待观察。事实上,在某些情况下,斑贴试验条件可能不是区分临床相关和不相关的香叶醇过敏的最佳方法。由于大量关于香叶醇阳性贴片试验出版物的出版物,未来需要努力确定这些出版物中有多少代表临床不耐受。这也将允许在贴片和使用测试中确定NOEL(未观察到的效应水平)。
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Is There Evidence that Geraniol Causes Allergic Contact Dermatitis?
The fragrance material geraniol has been cited as a frequent cause of allergic contact dermatitis. A review of the literature shows that when the underlying clinical and experimental data are analyzed, a clear cause-effect relationship has infrequently or rarely been established. On the basis of the generally weak sensitizing potential of this substance coupled with its generally low exposure conditions, the prevalence of clinical cases would not be expected to be particularly high. This is not to say that geraniol is a frequent inducer of type IV allergy in members of the public. It remains to be seen, however, how often such allergy, once established, is responsible for any of the cases of allergic contact dermatitis commonly ascribed in the literature. Indeed, in some cases, patch-test conditions may not be optimal for differentiating between clinically relevant and irrelevant allergy to geraniol. Because of the numerous publications on geraniol-positive patch-test publications, a future effort to ascertain how many of these represent clinical intolerance is indicated. This will also permit determination of the NOEL (no observed effect level) in patch and use testing.
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Acknowledgement to Referees for Exogenous Dermatology 2004 Contents Vol. 3, 2004 Author Index Vol. 3, 2004 Is There Evidence that Geraniol Causes Allergic Contact Dermatitis? Subject Index Vol. 3, 2004
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