Trandolapril

Papich Handbook of Veterinary Drugs Pub Date : 2021-01-01 DOI:10.18578/bnf.533283865

M. Papich

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引用次数: 1

摘要

一种具有抗高血压活性的非巯基血管紧张素转换酶(ACE)抑制剂。作为前药，曲多拉普利在肝脏中通过去酯化反应转化为活性形式曲多拉普利。T随机拉普利特竞争性地结合并抑制ACE，从而阻断血管紧张素I向血管紧张素II的转化。这阻止了血管紧张素II的有效血管收缩作用，导致血管舒张。T随机普利拉也减少血管紧张素ii诱导的肾上腺皮质醛固酮分泌，从而导致钠排泄增加，随后增加水分流出。Qeios·定义，2020年2月8日

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Trandolapril

A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. T randolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. T his prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. T randolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Qeios · Definition, February 8, 2020

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