香芹酚对大鼠肺挫伤的保护作用

O. Yakşi, Songül Peltek Özer
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摘要

背景:肺挫伤是急性胸外伤中常见的潜在危及生命的临床表现。如果在自然界中扩散,可能会危及生命。本研究探讨了抗氧化剂香芹酚对大鼠肺损伤的减轻作用。材料与方法:选用雌性Wistar Albino大鼠21只,体重240 ~ 320 g。采用2.25焦耳的能量,对孤立双侧肺挫伤模型进行修正,诱导肺挫伤。口服香芹酚50 mg/kg两剂量大鼠肺组织进行组织病理学检查。结果:各肺切片均见肺泡充血、肺泡破坏、肺泡出血、白细胞浸润。carvacrol组肺泡出血量明显低于对照组和创伤组(p = 0.033)。在carvacrol组中,充血、白细胞浸润和破坏也有所减少,尽管在统计学上不显著。结论:抗氧化剂香芹酚对外伤后肺挫伤肺泡出血有明显的预防作用。卡伐克罗组充血减少,无白细胞浸润。然而,这并不影响破坏。
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The parenchyma-protecting effect of carvacrol in pulmonary contusion induced in rats
Background: Pulmonary contusion is a potentially life-threatening clinical manifestation frequently seen in acute thoracic trauma. It can be life-threatening if diffuse in nature. This study investigated the tissue damage-reducing effect of carvacrol, an antioxidant, in rats with induced lung damage. Materials and Methods: Twenty-one female Wistar Albino rats weighing 240-320 g were used in the study. Pulmonary contusion was induced with the application of 2.25 joules of energy with a modification of the isolated bilateral pulmonary contusion model. Lung tissues of rats administered two doses of oral 50 mg/kg carvacrol were then subjected to histopathologic examination. Results: Congestion, alveolar destruction, alveolar hemorrhage, and leukocyte infiltration were subjected to histopathologic examination in all lung sections. The amount of alveolar hemorrhage was significantly lower in the carvacrol group compared with the control and trauma groups (p = 0.033). Congestion, leukocyte infiltration, and destruction also decreased, albeit statistically insignificantly, in the carvacrol group. Conclusion: The antioxidant carvacrol significantly prevented alveolar hemorrhage in pulmonary contusion developing following trauma. Congestion decreased, and no leukocyte infiltration developed in the carvacrol group. However, it did not affect destruction.
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