病毒疫苗策略

N.F. Khalaf
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摘要

背景:最近,许多病毒从默默无闻中出现或重新出现,成为对全球健康的重大威胁,引起了人们对其不断流行传播的警惕。这些病毒的一个非常重要的公共卫生问题是在免疫系统不成熟的易感宿主人群中持续传播。随着每一种新病毒的出现或重新出现,似乎都要求快速开发疫苗和诱导保护性免疫,因此,通过向濒危人口提供保护,这可能是预防这种关切的最有力工具之一。疫苗接种被认为是预防新出现的病毒感染疾病的关键组成部分之一,因为医疗解决方案的其他选择往往不存在或有限。尽管开发疫苗的传统方法仍然适用于新出现的病毒,但分子方法中最新技术的出现对病毒生物学的理解产生了深远的影响,以及基于减毒、复制和非复制病毒载体方法的免疫反应和疫苗接种方法成为疫苗接种的有益平台。结论:结合对新出现的病毒性疾病生物学的不断了解,最近已经开发了许多不同的疫苗接种策略,以防止再次出现新的病毒。研究发现,在所有用于制备病毒疫苗的策略中,最大的挑战是寻找成本低、高度专门化和效率高的疫苗,以应对新出现的病毒性疾病。在本文中,我们重点讨论了不同的病毒疫苗策略。
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Viral Vaccine Strategies
Background: Lately, many viruses emerged or re-emerged from the obscurity and became considerable threats to the global health, raising alarms concerning their constant epidemic transmissions. A very important public health concern of those viruses is the continuous circulation amongst the population of the immunologically naive, susceptible hosts. With each one of the new viral emergences or re-emergences, there appears a call for a fast development of a vaccination and induction of a protective immunity thus could be one of the most powerful tools for the prevention of that concern through conferring the protection to the endangered population.   Vaccinations have been considered one of the crucial components of disease preventions towards the emerging virus infections due to the fact that, often, other options for the medical solutions are non-existent or limited. Whereas the conventional methods for developing a vaccination remain amenable to the emerging viruses, advents of the newest technologies in the molecular methods have a profound influence on the understanding of the biology of the viruses, as well as immune responses and methods of vaccination that are based upon attenuated, replicating, and non-replicating virus vector methods became beneficial platforms for vaccination. Conclusion: In combination with a continuous understanding in biology of the newly appearing viral illnesses, a many different recent strategies of vaccination have been developed for protecting from the re-emerging and new viruses could become possible. It was found that the biggest challenge in all strategies used in the preparation of viral vaccines is to find vaccines that have a low cost, are highly specialized, and have high efficiency for the purpose of confronting emerging viral diseases.  In this paper we focus on different viral vaccines strategies.
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