The prognosis value of PT, DD and PLT and validation of the efficacy of the SIC score on initiating anticoagulant therapy in severe COVID-19 patients

Objective: To explore the prognosis value of PT, DD and PLT and validation of the efficacy of the SIC score on initiating anticoagulant therapy in severe COVID-19 patients Methods: We retrospectively enrolled 420 consecutive patients with severe COVID-19 admitted to Tongji Hospital of Huazhong University of Science and Technology in Wuhan from January 1 to February 11, 2020 A retrospective review of the characteristics of these patients(mainly including PT,DD, PLT and SIC score at the point of meeting severity criteria, underlying disease and so on) were collected through the electronic medical record system of our hospital The medications for anticoagulant therapy and outcomes (28-day mortality event) were also monitored 1 The patients were divided into Survivor group and Non-survivor group based on the event of 28 d motality the parameters of coagulation tests and clinical characteristics between these two groups were compared Furthermore, the association between PT, DD, PLT and 28-day mortality were analyzed by logistic regression analysis The predictive value of PT, DD, PLT for 28-day mortality were explored by ROC curve analysis 2 Based on the SIC score, the patients were divided into SIC group and Non-SIC group The 28-day mortality rates were compared among cases which were receiving anticoagulant therapy or not in SIC group and Non-SIC group The logistic regression was performed to validate the receiving anticoagulant therapy and 28-day mortality between SIC group and Non-SIC group Results: 1 PT in Non-survivor group was significantly prolonged compared with Survivor group[15 1(14 2, 16 6)s vs 14 3(13 6, 15 1s, Z=-5 922, P14 5s, DD>3 0 μg/ml and PLT14 5 s, DD>3 0 μg/ml and PLT<125×109/L were independent risk factors for 28-day mortality of severe COVID-19 patients;Initiating anticoagulant therapy guided by SIC score may improve the outcome of the specific patients with severe COVID-19