F. Ahmadi, K. Sadrjavadi, G. Mohammadi, Amir Separham, M. Barzegar-Jalali, M. Khoubnasabjafari, A. Jouyban
{"title":"25℃下对乙酰氨基酚在n -甲基-2-吡咯烷酮+乙醇+水混合物中的溶解度预测","authors":"F. Ahmadi, K. Sadrjavadi, G. Mohammadi, Amir Separham, M. Barzegar-Jalali, M. Khoubnasabjafari, A. Jouyban","doi":"10.6000/1929-5030.2014.03.03.4","DOIUrl":null,"url":null,"abstract":"The solubility of paracetamol in N-Methyl-2-pyrrolidone (NMP) + ethanol and NMP + ethanol + water solvent mixtures at 25 °C was determined using the shake flask method. The generated data extended the solubility database of pharmaceuticals and also was used to assess the solubility prediction capability of the Jouyban-Acree model in NMP + ethanol + water mixtures. The accuracy of the predicted solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental solubilities. The MPD of the Jouyban-Acree model for predicting the solubility of paracetamol in NMP + ethanol + water mixtures at 25 °C was 14.6 %.","PeriodicalId":15165,"journal":{"name":"Journal of Applied Solution Chemistry and Modeling","volume":"18 1","pages":"164-168"},"PeriodicalIF":0.0000,"publicationDate":"2014-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Solubility Prediction of Paracetamol in N-Methyl-2-pyrrolidone + Ethanol + Water Mixtures at 25 C\",\"authors\":\"F. Ahmadi, K. Sadrjavadi, G. Mohammadi, Amir Separham, M. Barzegar-Jalali, M. Khoubnasabjafari, A. Jouyban\",\"doi\":\"10.6000/1929-5030.2014.03.03.4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The solubility of paracetamol in N-Methyl-2-pyrrolidone (NMP) + ethanol and NMP + ethanol + water solvent mixtures at 25 °C was determined using the shake flask method. The generated data extended the solubility database of pharmaceuticals and also was used to assess the solubility prediction capability of the Jouyban-Acree model in NMP + ethanol + water mixtures. The accuracy of the predicted solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental solubilities. The MPD of the Jouyban-Acree model for predicting the solubility of paracetamol in NMP + ethanol + water mixtures at 25 °C was 14.6 %.\",\"PeriodicalId\":15165,\"journal\":{\"name\":\"Journal of Applied Solution Chemistry and Modeling\",\"volume\":\"18 1\",\"pages\":\"164-168\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Applied Solution Chemistry and Modeling\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.6000/1929-5030.2014.03.03.4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Solution Chemistry and Modeling","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6000/1929-5030.2014.03.03.4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Solubility Prediction of Paracetamol in N-Methyl-2-pyrrolidone + Ethanol + Water Mixtures at 25 C
The solubility of paracetamol in N-Methyl-2-pyrrolidone (NMP) + ethanol and NMP + ethanol + water solvent mixtures at 25 °C was determined using the shake flask method. The generated data extended the solubility database of pharmaceuticals and also was used to assess the solubility prediction capability of the Jouyban-Acree model in NMP + ethanol + water mixtures. The accuracy of the predicted solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental solubilities. The MPD of the Jouyban-Acree model for predicting the solubility of paracetamol in NMP + ethanol + water mixtures at 25 °C was 14.6 %.
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