Histione of the intestinal epithelial barrier in inflammatory bowel diseases: morphofunctional characteristics and clinical significance

From the modern standpoint of theoretical histology, the term "histione" is commonly understood to mean a temporary or permanent cellular association, whose combined functional activity is aimed at achieving significant structural and other types of homeostasis. The model concept of histione can be successfully applied to analyze the structure, function and their disorders, including characterizing the so- called intestinal epithelial barrier. The available scientific data indicate the involvement of increased intestinal permeability syndrome in the pathomorphogenesis of a number of diseases, including ulcerative colitis and Crohn's disease, related to inflammatory bowel diseases (IBD), which makes the problem of regulating the intestinal barrier permeability one of the most urgent for pathologists and clinicians. The article combines and organizes ideas about the histione of the intestinal epithelial barrier, the patterns of its regulation mechanisms in patients with IBD, as well as methods for assessing intestinal permeability in this patient cohort. KEYWORDS: histione, intestinal epithelial barrier, increased intestinal permeability, Crohn's disease, ulcerative colitis, inflammatory bowel diseases. FOR CITATION: Skalinskaya M.I., Deev R.V., Presnyakov E.V., Chekmareva I.A., Skazyvaeva E.V., Bakulin I.G. Histione of the intestinal epithelial barrier in inflammatory bowel diseases: morphofunctional characteristics and clinical significance. Russian Medical Inquiry. 2023;7(5):292–299 (in Russ.). DOI: 10.32364/2587-6821-2023-7-5-7.