基于5-羟基-7-甲氧基-2-苯基铬-4-酮的新药理活性化合物

Chemical Journal of Kazakhstan Pub Date : 2021-09-30 DOI:10.51580/2021-1/2710-1185.44

G. Baisarov, Karaganda Kazakhstan Production Holding “Phytochemistry”, S. Adekenov

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引用次数: 0

摘要

在碳酸钾存在下，5-羟基-7-甲氧基-2-苯基铬-4- 1与二溴代烷烃在丙酮中反应，根据迈克尔逆反应o-烷基化进行，生成相应的2-(溴代烷氧基)查尔酮。合成的化合物的结构经IR-、1H-和13C-NMR确证。本文首次对查尔酮衍生物(2-3)的细胞毒、保肝和抗炎作用进行了体内外实验研究。

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NEW PHARMACOLOGICALLY ACTIVE COMPOUNDS BASED ON 5-HYDROXY-7-METHOXY-2-PHENYLCHROMAN-4-ONE

The reaction of 5-hydroxy-7-methoxy-2-phenylchroman-4-one with dibromoalkanes in acetone in the presence of potassium carbonate proceeds according to the Michael’s retro-reaction O-alkylation and leads to the formation of the corresponding 2-(bromo-alkoxy) chalcones. The structure of the synthesized compounds was confirmed by IR-, 1H- and 13C-NMR spectroscopy. The cytotoxic, hepatoprotective and anti-inflammatory effects of chalcone derivatives (2-3) were studied for the first time in vitro and in vivo.

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Chemical Journal of Kazakhstan

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