Synaptic Reactions of the “Nociceptive” Neurons in the Cat Cortex up on Stimulation of the Periaqueductal Gray and Application of Some Pharmacological Agents

The problems of extracellular and intracellular signaling and its participation in control of the living systems are recognized to be one of the major directions in modern fundamental sciences, which are also used in clinical medicine for treatment and correction of the certain CNS disorders. The activity of cortical neurons that are related to the system of nociception, similarly to the activity of neurons of other cerebral nociceptive/ antinociceptive structures, is subjected to modulatory influences coming from a few brain centers.