一个案例研究-利用植物及其衍生物对癌细胞的调控和功能机制及其活性的控制

Palaniselvam Kuppusamy, Mashitah M. Yusoff, Gaanty Pragas Maniam, Natanamurugaraj Govindan
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引用次数: 20

摘要

许多独特的次生代谢产物及其生物学特性的发现是对传统医学认识的新开拓,是许多地方病的治疗所迫切需要的。这些植物在治疗地方病和非地方病方面具有悠久的民族药理学知识背景。传统上,这些植物以不同形式的膏状、提取物和粉末用于治疗季节性疾病。目前,一些药用植物的主要用途是治疗和控制各种慢性疾病,如癌症、艾滋病、肝炎、神经源性疾病和急性肾病。癌症是分子功能障碍和DNA碱基对的紊乱,导致人体生理生化行为的系统改变。凋亡机制是通过两种不同的途径调节的,这些途径的基本原理对所有真核生物都是一样的。细胞凋亡的关键成分,特别是线粒体胞内细胞器(DNA,蛋白质和ATP, Ca2+)被确定。这些成分控制下一个细胞结合步骤,并参与影响细胞自杀机制。线粒体参与细胞凋亡的不同方面包括处理其他过程,如释放蛋白质或酶以有效地导致细胞死亡。在这些机制中,植物及相关天然产物采用替代治疗管理,毒性非常小,成本效益高。植物提取物及其生物量揭示了类固醇、多酚、多糖、皂苷、生物碱、单宁和萜类化合物等多种药理活性物质的存在。这些可靠的天然产品是抗癌药物的高来源。天然衍生化合物是延长沸石寿命,减少细胞系统恶性细胞的形成。
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A case study – Regulation and functional mechanisms of cancer cells and control its activity using plants and their derivatives

Novel exploiting to the understanding of conventional medicine was followed by the findings of many unique secondary metabolites and its biological property and is highly required for treating of many endemic diseases. The plants have been a long background in ethno pharmacological knowledge for treatment of endemic and non-endemic diseases. Such plants are traditionally used in different form of paste, extraction and powder to treat seasonal diseases. Nowadays main uses of some medicinal plants have been a great deal with cure and control various chronic diseases such as cancer, AIDS, hepatitis, neurogenic disorders and acute kidney diseases. Cancer is molecular dysfunction and disarrangement in DNA base pairs it leads to change the human physiological and biochemical behavior of the system. Apoptotic mechanisms are regulating by two distinct pathways in which basic creeds perform in common to all eukaryotes. The key components in apoptosis especially mitochondrial intracellular organelles are identified (DNA, protein and ATP, Ca2+). These components control the next cellular binder step and participate in effecting cell suicide mechanisms. The diverse aspects of mitochondria involved in apoptosis include dealing with other proceedings such as release of protein or enzymes to effective for cell death. In these mechanism plants and related natural products using alternative therapeutic management, very less toxicity and cost benefits. Plant extracts and its biomass has revealed the existing of various pharmacologically active compounds like steroids, polyphenols, polysaccharides, saponins, alkaloids, tannins and terpenoids. The reliable natural products are acting as high sources for anticancer drugs. The natural derived compounds are the prolongation of life span of the zeolites and decrease of malignancy cell formation in the cellular system.

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