Jing-tao Wu, Lei Zhou, Gui-wen Yang, F. Tao, Mao-shan Wang, Jian-guo Hu
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引用次数: 0
摘要
背景:桔梗素D (Platycodin D, PD)是桔梗(Platycodon grandflorum，桔梗)根中重要的活性成分之一。a . DC (PG)，一种具有多种药理活性的传统药物，尤其是保肝活性。对其保护肝脏的机制有一些研究，但还不是很清楚。有必要对此进行深入调查。材料与方法:为评价PD对乙醇性脂肪肝(EFL)的影响并探讨其可能的机制，建立大鼠EFL模型和BRL-3A细胞，分别给予20、30 mg/kg体重/天PD处理4周。测定大鼠肝脏组织化学、肝功能酶、氧化应激水平、抗氧化酶和信号通路酶。结果:PD显著(P
IMPROVING EFFECT OF PLATYCODIN D ON ETHANOL-INDUCED FATTY LIVER VIA KEAP1-NRF2-ARE SIGNAL PATH
Background: Platycodin D (PD) is one of the important active ingredients in the root of the Platycodon grandiflorum
(Jacq.) A. DC (PG), a traditional medicine with many pharmacological activities, especially hepatoprotective activity.
There are some researches on the mechanism of liver protection, but it is not very clear. It is necessary to investigate it
deeply.
Materials and Methods: In order to evaluate the effect of PD on ethanol-induced fatty liver (EFL) and investigate the
possible mechanism, the EFL models of rats and BRL-3A cells were set up and treated with PD of 20, 30 mg/kg body
weight/day for four weeks, respectively. The hepatic histochemistry, liver function enzymes, oxidative stress levels,
antioxidant enzymes and signal path enzymes were assayed.
Results: PD significantly (P
期刊介绍：
The “African Journal of Traditional, Complementary and Alternative Medicines (AJTCAM)” is a peer-reviewed, multidisciplinary, international, scientific Open Access Journal that provides publication of articles on phytomedicines, ethnomedicines and veterinary ethnomedicines. The journal is published by a Non-Governmental Organization (NGO) known as “African Traditional Herbal Medicine Supporters Initiative (ATHMSI)”. The Journal welcomes submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published approximately two-to-three months after acceptance
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