膀胱尿路上皮癌中雄激素受体的表达及其与已知预后因素的关系

Eman T. El-taher, M. Zamzam, A. Elzawawy, W. Hassan, Marwa A. Suliman
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引用次数: 0

摘要

目的:本研究旨在评估雄激素受体表达在膀胱尿路上皮癌中的预后价值,并将其与疾病结局联系起来。方法:对经组织学证实的膀胱尿路上皮癌病例进行研究。收集临床、病理和放射学资料。石蜡包埋切片进行苏木精和伊红染色,免疫组化染色检测肿瘤细胞雄激素受体。结果:核雄激素受体在75%的组织病理标本中表达阳性。此外,雄激素受体表达与肿瘤分级、肌肉侵袭和肿瘤大小呈正相关。结论:尿路上皮性膀胱癌的肿瘤大、分级高、浸润深度与雄激素受体的表达有显著相关性。抗雄激素可作为一种有效的预防或治疗尿路上皮性膀胱癌的化疗方法。
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Androgen receptor expression in the urinary bladder urothelial carcinoma and its relation to known prognostic factors
Objective: The current study was carried out to assess the prognostic value of androgen receptor expression in urothelial carcinoma of the bladder and correlate it to the disease outcome. Methods: Histologically confirmed cases of bladder urothelial carcinoma were studied. Clinical, pathological, and radiological data were collected. Paraffin embedded tissue sections were submitted for hematoxylin and eosin staining, as well as immunohistochemical staining for androgen receptor in tumor cells. Results: Nuclear androgen receptor expression was positive in 75% of the studied histopathological specimens. Additionally, a significant positive association between androgen receptor expression and tumor grade, muscle invasion & tumor size were noticed. Conclusions: There is a significant association between large tumor size, high grade, deep invasion, and expression of Androgen receptor in urothelial bladder carcinoma. Antiandrogen could be an effective chemo preventive or therapeutic approach in treatment of urothelial bladder carcinoma.
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