Joana K Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz M Abad, B. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, M. Johansson, G. Hansson, G. Birchenough
{"title":"Nlrp6炎性小体不是结肠内黏液层形成或功能所必需的","authors":"Joana K Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz M Abad, B. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, M. Johansson, G. Hansson, G. Birchenough","doi":"10.1084/jem.20190679","DOIUrl":null,"url":null,"abstract":"It is thought that the Nlrp6 inflammasome regulates formation of the inner mucus layer (IML) barrier that prohibits contact between the microbiota and colonic epithelial cells. Using microbiota-controlled mice and combined ex vivo/in vivo IML analytical approaches, Volk et al. delineate the relative roles of the inflammasome and microbiota in shaping IML formation and function.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"10 26 1","pages":"2602 - 2618"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"69","resultStr":"{\"title\":\"The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function\",\"authors\":\"Joana K Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz M Abad, B. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, M. Johansson, G. Hansson, G. Birchenough\",\"doi\":\"10.1084/jem.20190679\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"It is thought that the Nlrp6 inflammasome regulates formation of the inner mucus layer (IML) barrier that prohibits contact between the microbiota and colonic epithelial cells. Using microbiota-controlled mice and combined ex vivo/in vivo IML analytical approaches, Volk et al. delineate the relative roles of the inflammasome and microbiota in shaping IML formation and function.\",\"PeriodicalId\":23015,\"journal\":{\"name\":\"The Tokushima journal of experimental medicine\",\"volume\":\"10 26 1\",\"pages\":\"2602 - 2618\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-08-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"69\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Tokushima journal of experimental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1084/jem.20190679\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20190679","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function
It is thought that the Nlrp6 inflammasome regulates formation of the inner mucus layer (IML) barrier that prohibits contact between the microbiota and colonic epithelial cells. Using microbiota-controlled mice and combined ex vivo/in vivo IML analytical approaches, Volk et al. delineate the relative roles of the inflammasome and microbiota in shaping IML formation and function.
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