在T细胞活化过程中，共刺激诱导的AP-1活性是染色质打开所必需的

The Tokushima journal of experimental medicine Pub Date : 2019-10-25 DOI:10.1084/jem.20182009

M. Yukawa, S. Jagannathan, Sushmitha Vallabh, A. Kartashov, Xiaoting Chen, M. Weirauch, A. Barski

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引用次数: 60

摘要

AP-1转录因子在T细胞活化过程中被募集到大多数染色质重塑位点。AP-1的活性是由共刺激诱导的，是染色质打开所必需的。重塑位点与免疫性疾病的危险位点重叠。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation

AP-1 transcription factor is recruited to the majority of chromatin remodeling sites during T cell activation. The activity of AP-1 is induced by co-stimulation and is required for chromatin opening. The sites of remodeling overlap with risk loci of immunological diseases.

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The Tokushima journal of experimental medicine

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