α-硫辛酸治疗后男性1型糖尿病患者的脂质过氧化过程

IF 0.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL AIMS Medical Science Pub Date : 2021-01-01 DOI:10.3934/medsci.2021024
M. Darenskaya, E. Chugunova, S. Kolesnikov, N. Semenova, O. Nikitina, L. Kolesnikova
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引用次数: 0

摘要

在各种病理情况下,如糖尿病,细胞氧化还原平衡可能被扰乱,这些改变可能在血糖水平恢复正常后持续存在。抗氧化疗法,包括α-硫辛酸,被广泛用于治疗包括糖尿病在内的各种全身性疾病。本研究旨在测定α-硫辛酸治疗1型糖尿病(T1DM)患者的脂质代谢参数、脂质过氧化活性及抗氧化防御反应。对24例血糖不理想的育龄T1DM男性进行检查。28名年龄相仿的健康男性作为对照组。采用分光光度法、荧光法和酶联免疫分析法。T1DM的特征是脂质代谢成分增加,包括总胆固醇、甘油三酯(TG)和极低密度脂蛋白(VLDL)。在脂质过氧化系统中,与对照组相比,在T1DM患者中观察到初级产物(共轭二烯)、次级产物(硫代巴比妥酸反应物)和最终产物(希夫碱)的水平升高。视黄醇值也增加了。治疗后,与治疗前相比,TG、VLDL和希夫碱水平降低,视黄醇水平升高。这些结果扩大了我们对T1DM发病机制的理解,并提示α-LA治疗可能对1型糖尿病患者有益。
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Lipid peroxidation processes in men with type 1 diabetes mellitus following α-lipoic acid treatment
In various pathological conditions such as diabetes mellitus, the cellular redox balance can be disturbed and these alterations may persist even after blood glucose levels have returned to normal. Antioxidant therapies, including α-lipoic acid, are widely used to treat various systemic diseases including diabetes mellitus. The aim of this study was to measure the lipid metabolism parameters, as well as the activity of lipid peroxidation and antioxidant defense reactions, in men with type 1 diabetes mellitus (T1DM) during treatment with α-lipoic acid. Twenty-four reproductive-age T1DM males with an unsatisfactory glycemic profile were examined. Twenty-eight practically healthy men of similar age were used as the control group. Spectrophotometric, fluorometric, and enzyme-linked immunoassay methods were used. T1DM was characterized by increased values of lipid metabolism components, including total cholesterol, triacylglycerides (TG), and very-low-density lipoproteins (VLDL). In the lipid peroxidation system, increased levels of the primary products (conjugated dienes), secondary products (thiobarbituric acid reactants), and final products (Schiff bases) were observed in T1DM patients compared to the control group. Retinol values were also increased. After treatment, there was a decrease in TG, VLDL, and Schiff bases levels and an increase in the retinol level compared to before treatment. These results expand our understanding of the pathogenetic mechanisms of T1DM and suggest that α-LA treatment may be beneficial for type 1 diabetics.
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来源期刊
AIMS Medical Science
AIMS Medical Science MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
14.30%
发文量
20
审稿时长
12 weeks
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