Immune dysfunction induced by myeloid-derived suppressor cells in lymphoma

Lymphoma cancer cells have strongly orchestrated interactions with immune cells and also other surrounding stromal cells in tumor microenvironment. Myeloid derived suppressor cells (MDSC) is believed to have major role in induction of immune suppressive effects in tumor microenvironment. This heterogeneous population of immature myeloid cells influence on immune cells function by indirectly Treg differentiation and directly oxidative stress induction and nutrient depletion in tumor milieu. Our understanding of the role of MDSCs in tumor microenvironment suggests novel immunotherapeutic approaches and need to be more explored. In this article we briefly discuss the main MDSCs immune dysfunction mechanisms with more focus in lymphoma.