{"title":"非平冲头位置对单侧压实法压痕片分型性能的影响","authors":"A. Ito, M. Sugihara","doi":"10.5649/jjphcs1975.17.306","DOIUrl":null,"url":null,"abstract":"The significance of the position of nonflat punch on dividing prcperties of scored tablets was investigated in several tablets prepared from excipients or granules by one side compaction method.For the excipients, lactose, perfiller®and microcrystalline cellulose were used.For the granules, sieved granules in 12-16, 16-32 and 32-48 mesh incorporating either hydroxy propyl cellulose or potato starch as binder was used.Different influence of the position of nonflat punch on dividing strength of scored tablets was observed between the case of excipients and granules.Dividing strength of scored tablets made from excipients was not affected by the position of nonflat punch.But tablets made from granules had a tendency to show high dividing strength when tablets were compressed by nonflat upper punch.Then weight variation of divided tablets showed a tendency to become less when compressed by nonflat upper punch in both tablets made from excipients and granules.It was suggested that the effect of the position of nonflat punch on dividing properties of scored tablets was caused by different pressure lines during tablet compression.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"7 1","pages":"306-311"},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Position of Nonflat Punch on-Dividing Properties of Scored Tablet in One Side Compaction Method\",\"authors\":\"A. Ito, M. Sugihara\",\"doi\":\"10.5649/jjphcs1975.17.306\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The significance of the position of nonflat punch on dividing prcperties of scored tablets was investigated in several tablets prepared from excipients or granules by one side compaction method.For the excipients, lactose, perfiller®and microcrystalline cellulose were used.For the granules, sieved granules in 12-16, 16-32 and 32-48 mesh incorporating either hydroxy propyl cellulose or potato starch as binder was used.Different influence of the position of nonflat punch on dividing strength of scored tablets was observed between the case of excipients and granules.Dividing strength of scored tablets made from excipients was not affected by the position of nonflat punch.But tablets made from granules had a tendency to show high dividing strength when tablets were compressed by nonflat upper punch.Then weight variation of divided tablets showed a tendency to become less when compressed by nonflat upper punch in both tablets made from excipients and granules.It was suggested that the effect of the position of nonflat punch on dividing properties of scored tablets was caused by different pressure lines during tablet compression.\",\"PeriodicalId\":17399,\"journal\":{\"name\":\"Journal of the Nippon Hospital Pharmacists Association\",\"volume\":\"7 1\",\"pages\":\"306-311\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Nippon Hospital Pharmacists Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5649/jjphcs1975.17.306\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Nippon Hospital Pharmacists Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5649/jjphcs1975.17.306","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of Position of Nonflat Punch on-Dividing Properties of Scored Tablet in One Side Compaction Method
The significance of the position of nonflat punch on dividing prcperties of scored tablets was investigated in several tablets prepared from excipients or granules by one side compaction method.For the excipients, lactose, perfiller®and microcrystalline cellulose were used.For the granules, sieved granules in 12-16, 16-32 and 32-48 mesh incorporating either hydroxy propyl cellulose or potato starch as binder was used.Different influence of the position of nonflat punch on dividing strength of scored tablets was observed between the case of excipients and granules.Dividing strength of scored tablets made from excipients was not affected by the position of nonflat punch.But tablets made from granules had a tendency to show high dividing strength when tablets were compressed by nonflat upper punch.Then weight variation of divided tablets showed a tendency to become less when compressed by nonflat upper punch in both tablets made from excipients and granules.It was suggested that the effect of the position of nonflat punch on dividing properties of scored tablets was caused by different pressure lines during tablet compression.
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