Ferroptosis and cancer: interlinkages and potential applications

The buildup of lipid peroxides on the cell membrane is critical in the initiation of Ferroptosis, an iron-dependent form of controlled cell death. Ferroptosis is a type of cell death that varies from other types of cell death in both mechanics and morphology, and it holds significant promise for cancer therapy. As a result, there has been increasing interest in the cancer research community regarding the exploration and understanding of Ferroptosis in recent years. This review article aims to provide a solid theoretical foundation for the management of Ferroptosis in cancer. It accomplishes this by summarizing the processes that contribute to the development of Ferroptosis and outlining the underlying mechanisms of Ferroptosis in various types of tumors.