Pandemic COVID-19 Emerging Global Concern: An Overview to Understand the Potential of Ca+2 in Pathogenesis and Advance Therapeutics Strategy on its Outbreak

The new public health crisis is threatening the world with the emerging and spread of coronavirus. In December 2019, a series of pneumonia and acute respiratory disease caused by novel corona virus SARS-CoV-2 had been appeared in china and spread out worldwide. World Health Organization (WHO) officially declared its name COVID-19 and ‘pandemic’ as a public health emergency in February 2020. Novel corona virus SARS-CoV-2 marked the third introduction of highly pathogenic and large-scale epidemic coronavirus into humans after SARS and MERS. As of till the end of June, a total of more than 1 crore confirmed cases were reported globally. USA, Brazil, Italy, India and Spain are leading affected countries, and around 5 lakh peoples have been died due to the global pandemic according to the WHO report. Meanwhile, several research groups studies suggested that it is likely the zoonotic origin of COVID-19 and person to person transmission has led the pandemic disease. Based on the published evidence, we systematically discussed and summarized the characteristics of novel corona virus SARSCoV-2 and the role of receptor and protein in host-pathogen interaction. Evidence from previous studies suggests that knowledge regarding prevention and its treatment is still scarce. In this review, we have revealed the One-Health perspective and reservoir, biology of transmission, survival mechanism, and the potential role of Ca+2 ions in the pathogenesis mechanism of SARS-CoV-2, diagnosis characteristic symptoms, possible treatment and prevention in terms of One-Health from COVID-19. Along with this it also provides an essential insight into the control measures that would minimize the potential risk of disease transmission and will be helpful for vaccine development against the pandemic COVID-19.