{"title":"2-[(E)-(4-羟基-3-{(E)-[(喹啉-2-基)亚氨基]甲基}苯基)二氮基]苯甲酸的二丁基锡配合物:合成、光谱及体外抗真菌活性","authors":"M. Roy, Jhinuk De","doi":"10.30492/IJCCE.2021.532179.4793","DOIUrl":null,"url":null,"abstract":"ABSTRACT: Dibutyltin(IV) complex of 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2-yl)imino] methyl} phenyl) diazenyl]benzoic acid was synthesized by refluxing 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2- yl) imino] methyl} phenyl) diazenyl]benzoic acid with dibutyltin(IV) oxide in hot toluene. The complex was characterized by elemental analysis in combination with UV-visible, IR, 1H, 13C, 119Sn NMR spectroscopy and Mass spectrometry technique. The carboxylate ligand acts as chelating bidentate mode of coordination with the tin atom in the complex. The complex exhibited cyclic dimeric structure in the solution state where the tin centers adopt 6- coordinate octahedral geometry. The in vitro antifungal property of the ligand and the complex was observed and compared with reference drug, Amphotericin-B.","PeriodicalId":14572,"journal":{"name":"Iranian Journal of Chemistry & Chemical Engineering-international English Edition","volume":"36 1","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2021-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dibutyltin(IV) complex of 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2-yl)imino] methyl} phenyl) diazenyl]benzoic acid: Synthesis, spectroscopy and in vitro antifungal activity\",\"authors\":\"M. Roy, Jhinuk De\",\"doi\":\"10.30492/IJCCE.2021.532179.4793\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"ABSTRACT: Dibutyltin(IV) complex of 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2-yl)imino] methyl} phenyl) diazenyl]benzoic acid was synthesized by refluxing 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2- yl) imino] methyl} phenyl) diazenyl]benzoic acid with dibutyltin(IV) oxide in hot toluene. The complex was characterized by elemental analysis in combination with UV-visible, IR, 1H, 13C, 119Sn NMR spectroscopy and Mass spectrometry technique. The carboxylate ligand acts as chelating bidentate mode of coordination with the tin atom in the complex. The complex exhibited cyclic dimeric structure in the solution state where the tin centers adopt 6- coordinate octahedral geometry. The in vitro antifungal property of the ligand and the complex was observed and compared with reference drug, Amphotericin-B.\",\"PeriodicalId\":14572,\"journal\":{\"name\":\"Iranian Journal of Chemistry & Chemical Engineering-international English Edition\",\"volume\":\"36 1\",\"pages\":\"\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2021-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Chemistry & Chemical Engineering-international English Edition\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.30492/IJCCE.2021.532179.4793\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Chemistry & Chemical Engineering-international English Edition","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.30492/IJCCE.2021.532179.4793","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Dibutyltin(IV) complex of 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2-yl)imino] methyl} phenyl) diazenyl]benzoic acid: Synthesis, spectroscopy and in vitro antifungal activity
ABSTRACT: Dibutyltin(IV) complex of 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2-yl)imino] methyl} phenyl) diazenyl]benzoic acid was synthesized by refluxing 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2- yl) imino] methyl} phenyl) diazenyl]benzoic acid with dibutyltin(IV) oxide in hot toluene. The complex was characterized by elemental analysis in combination with UV-visible, IR, 1H, 13C, 119Sn NMR spectroscopy and Mass spectrometry technique. The carboxylate ligand acts as chelating bidentate mode of coordination with the tin atom in the complex. The complex exhibited cyclic dimeric structure in the solution state where the tin centers adopt 6- coordinate octahedral geometry. The in vitro antifungal property of the ligand and the complex was observed and compared with reference drug, Amphotericin-B.
期刊介绍:
The aim of the Iranian Journal of Chemistry and Chemical Engineering is to foster the growth of educational, scientific and Industrial Research activities among chemists and chemical engineers and to provide a medium for mutual communication and relations between Iranian academia and the industry on the one hand, and the world the scientific community on the other.