孤立性纤维性肿瘤-胸膜腔少见的肿瘤。

Š. Vejvodová, V. Špidlen, P. Mukeňsnabl, G. Krákorová, J. Molacek, J. Vodička
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引用次数: 6

摘要

单发纤维性肿瘤(SFT)是一种异质性的原发性胸膜肿瘤,发病率低,其生物学起源(由间充质细胞组成)尚不确定。方法回顾性分析2000-2015年间诊断和手术治疗的22例SFTs患者。术前有27.3%的患者在CT控制下经胸穿刺活检成功证实了肿瘤的形态。手术入路为后外侧开胸或胸腔镜。随访中位为45个月(范围1-188个月)。结果20例肿瘤均行根治性手术切除,2例因肿瘤体积较大而无法切除。从组织学上看,81.8%的肿瘤为低恶性潜能的SFT, 18.2%的肿瘤为高恶性潜能的SFT。尽管根治了SFT,但仍有两名患者复发。结论根治性手术切除是治疗SFT的金标准;然而,有复发风险的患者需要额外的随访。辅助治疗复发和恶性SFTs的结果是讨论和进一步研究的主题。
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Solitary Fibrous Tumor - Less Common Neoplasms of the Pleural Cavity.
PURPOSE solitary fibrous tumors (SFT) represent a heterogeneous group of primary pleural neoplasms with a low incidence rate and of which the biological origin, which consists of mesenchymal cells, is uncertain. METHODS The authors present herewith a retrospective analysis of 22 patients with SFTs who were diagnosed and surgically treated between the years 2000-2015. The preoperative tumors were successfully verified morphologically by transthoracic core needle biopsy under CT control in 27.3% of patients. Surgical approaches were either posterolateral thoracotomy or videothoracoscopy. The follow-up median was 45 months (range 1-188 months). RESULTS Twenty tumors were surgically removed radically, two tumors were found to be unresectable due to the considerable tumor size. From histological point of view 81.8% of tumors were SFT with low malignant potential, 18.2% of tumors with high malignant potential. Despite the radical extirpation of the SFT, it relapsed in two patients. CONCLUSION The gold standard of SFT treatment is radical surgical removal; however, patients at risk of recurrence require additional follow-ups. The results of adjuvant therapy in recurrent and malignant forms of SFTs are the subject of discussion and further study.
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