氯硝西泮治疗癫痫儿童的血药浓度

N. Morikawa, K. Ikawa, Taturo Izumi, M. Takeyama
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摘要

我们讨论氯硝西泮(CZP)与其他抗惊厥药物在癫痫患儿中的血药浓度与临床剂量的关系。采用高效液相色谱法测定141例儿童(男73例,女68例)610份血药浓度。我们发现本院CZP临床剂量低于《Goodman and Gilman’s the pharmacology Basis of Therapeutics》和《美国药典配药信息》中所规定的剂量,因此血药浓度随剂量呈相应的低范围分布。观察到CZP的血药浓度与临床剂量之间存在相关性,且相关性与患者的性别和年龄有关。老年组(11岁以上)血浆CZP浓度高于年轻组(0 ~ 10岁),男性组高于女性组。我们调查了两名患者长期血浆浓度和剂量之间的关系。结果表明,有必要在剂量和体重变化的情况下长期监测CZP的治疗药物。
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Plasma Concentrations of Clonazepam Therapy in Epileptic Children
We discuss the correlation between plasma concentration and clinical dose of Clonazepam (CZP) combined with other anticonvulsants in epileptic children. The plasma concentrations were measured in 610 samples from 141 children (73 males and 68 females) by HPLC method. We found that the clinical doses of CZP in our hospital were lower than those directed in “Goodman and Gilman's The Pharmacological Basis of Therapeutics” and in “United States Pharmacopoeia Dispensing Information”, and that therefore the plasma concentrations were distributed at the low range correspondingly with doses. A correlation between plasma concentration and clinical doses of CZP was observed and the relationship depended on sex and age of the patients. The plasma concentration of CZP in the older group (over 11 years old) was higher than that in the younger group (from 0 to 10 years old) and that in the male group was higher than that in the female group.We surveyed the relationship between the plasma concentration and dose of CZP in two patients over the longterm. The results indicated the necessity for frequent therapeutic drug monitoring of CZP over the longterm at the changes of dose and patient weight.
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