Recent graft materials in experimental study stage used in the treatment of nasal septum perforation: a review

Various conservative approaches are being used for the treatment of nasal septum perforations (NSPs); however, for permanent results, it is essential to use surgical methods. For this purpose, many various surgical methods have been tried, but a satisfactory method has not yet been determined. In order to eliminate the commonly encountered failure of surgical methods, new graft materials combined with flaps have been tried recently and successful results have been reported. In this review, we examined the scientific literature using Medline, PubMed, and Google by using the keywords "nasal septum perforation", "animal study", and "graft". According to the results obtained, we compiled graft materials that have been used in experimental stage related to this subject and reported to have achieved successful results, especially when combined with flaps. These materials seem promising for the successful closure of the hard-to-treat NSPs.