慢性阻塞性肺疾病患者血清脂脂素和IL-6水平

IF 1.8 Q3 RESPIRATORY SYSTEM Advances in respiratory medicine Pub Date : 2022-09-07 DOI:10.3390/arm90050049
Mohammad Reza Aslani, Mojtaba Amani, Faranak Moghadas, Hassan Ghobadi
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引用次数: 2

摘要

目的:脂polin是一种具有胰岛素增敏特性的脂肪因子,其水平降低在肥胖、氧化应激和炎症中都有报道。本研究探讨了慢性阻塞性肺疾病(COPD)患者血清白细胞介素-6 (IL-6)和脂脂素水平。方法:选取60例慢性阻塞性肺病患者和30例健康人作为对照,测定血清脂polin和IL-6水平。此外,根据GOLD分级评估COPD患者血清脂polin水平。分析了血清脂脂素水平与研究变量之间的关系。结果:COPD患者的脂脂素水平低于健康人(p < 0.001)。此外,与对照组相比,COPD组IL-6水平明显升高(p < 0.001)。血脂素水平与pft呈正相关,与IL-6水平呈负相关。结论:脂脂素水平降低可提高COPD患者的疾病严重程度。脂polin与IL-6之间存在显著关系,可能提示脂polin在COPD病理生理中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Adipolin and IL-6 Serum Levels in Chronic Obstructive Pulmonary Disease.

Objective(s): One of the adipokines that have insulin-sensitizing properties is adipolin, whose reduced levels have been reported in obesity, oxidative stress, and inflammation. The present study investigated serum interleukin-6 (IL-6) and adipolin levels in chronic obstructive pulmonary disease (COPD) patients. Method: A control case study included 60 COPD patients and 30 healthy subjects in the research and measured adipolin and IL-6 serum levels. In addition, serum adipolin levels in COPD patients were assessed according to the GOLD grade. The relationship between serum adipolin levels and study variables were also analyzed. Results: The results showed reduced adipolin levels in COPD patients compared with healthy individuals (p < 0.001). Furthermore, increased levels of IL-6 were evident in the COPD group compared to the control group (p < 0.001). Adipolin serum levels were positively correlated with PFTs and negatively correlated with IL-6 levels. Conclusion: Decreased adipolin levels enhanced disease severity in COPD patients. It seems that the existence of a significant relationship between adipolin and IL-6 may indicate the role of adipolin in the pathophysiology of COPD.

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来源期刊
Advances in respiratory medicine
Advances in respiratory medicine RESPIRATORY SYSTEM-
CiteScore
2.60
自引率
0.00%
发文量
90
期刊介绍: "Advances in Respiratory Medicine" is a new international title for "Pneumonologia i Alergologia Polska", edited bimonthly and addressed to respiratory professionals. The Journal contains peer-reviewed original research papers, short communications, case-reports, recommendations of the Polish Respiratory Society concerning the diagnosis and treatment of lung diseases, editorials, postgraduate education articles, letters and book reviews in the field of pneumonology, allergology, oncology, immunology and infectious diseases. "Advances in Respiratory Medicine" is an open access, official journal of Polish Society of Lung Diseases, Polish Society of Allergology and National Research Institute of Tuberculosis and Lung Diseases.
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