Hong-Rui Chen, Mei Xue, Hao Zhou, Yao-Gong Wu, Yan Chen, Wan-Xin Chen
{"title":"一例新冠肺炎所致肺纤维化患者双隆移植术后近平滑念珠菌感染。","authors":"Hong-Rui Chen, Mei Xue, Hao Zhou, Yao-Gong Wu, Yan Chen, Wan-Xin Chen","doi":"10.25259/Cytojournal_67_2020","DOIUrl":null,"url":null,"abstract":"<p><p>Pulmonary fibrosis is a complication in patients with coronavirus disease 2019 (COVID-19). Extensive pulmonary fibrosis is a severe threat to patients' life and lung transplantation is last resort to prolong the life of patients. We reported a case of critical type COVID-19 patient, though various treatment measures were used, including anti-virus, anti-infection, improving immunity, convalescent plasma, prone position ventilation, and airway cleaning by fiber-optic bronchoscope, although his COVID-19 nucleic acid test turned negative, the patient still developed irreversible extensive pulmonary fibrosis, and respiratory mechanics suggested that lung compliance could not be effectively recovered. After being assisted by ventilator and extracorporeal membrane oxygenation for 73 days, he finally underwent double-lung transplantation. On the 2<sup>nd</sup> day after the operation, the alveolar lavage fluid of transplanted lung was examined by cytomorphology, and the morphology of alveolar epithelial cells was intact and normal. On the 20<sup>th</sup> day post-transplantation, the chest radiograph showed a large dense shadow in the middle of the right lung. On the 21<sup>st</sup> day, the patient underwent fiber-optic bronchoscopy, yeast-like fungal spores were found by cytomorphological examination from a brush smear of the right bronchus, which was confirmed as <i>Candida parapsilosis</i> infection by fungal culture. He recovered well due to the careful treatment and nursing in our hospital. Until July 29, 96 days after transplantation, the patient was recovery and discharged from hospital.</p>","PeriodicalId":49082,"journal":{"name":"Cytojournal","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2023-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990843/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>Candida parapsilosis</i> infection after double-lung transplantation in a patient with pulmonary fibrosis caused by COVID-19.\",\"authors\":\"Hong-Rui Chen, Mei Xue, Hao Zhou, Yao-Gong Wu, Yan Chen, Wan-Xin Chen\",\"doi\":\"10.25259/Cytojournal_67_2020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pulmonary fibrosis is a complication in patients with coronavirus disease 2019 (COVID-19). Extensive pulmonary fibrosis is a severe threat to patients' life and lung transplantation is last resort to prolong the life of patients. We reported a case of critical type COVID-19 patient, though various treatment measures were used, including anti-virus, anti-infection, improving immunity, convalescent plasma, prone position ventilation, and airway cleaning by fiber-optic bronchoscope, although his COVID-19 nucleic acid test turned negative, the patient still developed irreversible extensive pulmonary fibrosis, and respiratory mechanics suggested that lung compliance could not be effectively recovered. After being assisted by ventilator and extracorporeal membrane oxygenation for 73 days, he finally underwent double-lung transplantation. On the 2<sup>nd</sup> day after the operation, the alveolar lavage fluid of transplanted lung was examined by cytomorphology, and the morphology of alveolar epithelial cells was intact and normal. On the 20<sup>th</sup> day post-transplantation, the chest radiograph showed a large dense shadow in the middle of the right lung. On the 21<sup>st</sup> day, the patient underwent fiber-optic bronchoscopy, yeast-like fungal spores were found by cytomorphological examination from a brush smear of the right bronchus, which was confirmed as <i>Candida parapsilosis</i> infection by fungal culture. He recovered well due to the careful treatment and nursing in our hospital. 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Candida parapsilosis infection after double-lung transplantation in a patient with pulmonary fibrosis caused by COVID-19.
Pulmonary fibrosis is a complication in patients with coronavirus disease 2019 (COVID-19). Extensive pulmonary fibrosis is a severe threat to patients' life and lung transplantation is last resort to prolong the life of patients. We reported a case of critical type COVID-19 patient, though various treatment measures were used, including anti-virus, anti-infection, improving immunity, convalescent plasma, prone position ventilation, and airway cleaning by fiber-optic bronchoscope, although his COVID-19 nucleic acid test turned negative, the patient still developed irreversible extensive pulmonary fibrosis, and respiratory mechanics suggested that lung compliance could not be effectively recovered. After being assisted by ventilator and extracorporeal membrane oxygenation for 73 days, he finally underwent double-lung transplantation. On the 2nd day after the operation, the alveolar lavage fluid of transplanted lung was examined by cytomorphology, and the morphology of alveolar epithelial cells was intact and normal. On the 20th day post-transplantation, the chest radiograph showed a large dense shadow in the middle of the right lung. On the 21st day, the patient underwent fiber-optic bronchoscopy, yeast-like fungal spores were found by cytomorphological examination from a brush smear of the right bronchus, which was confirmed as Candida parapsilosis infection by fungal culture. He recovered well due to the careful treatment and nursing in our hospital. Until July 29, 96 days after transplantation, the patient was recovery and discharged from hospital.
期刊介绍:
The CytoJournal is an open-access peer-reviewed journal committed to publishing high-quality articles in the field of Diagnostic Cytopathology including Molecular aspects. The journal is owned by the Cytopathology Foundation and published by the Scientific Scholar.