压力、抑郁和海马体:从生物化学到电生理学。

IF 1.3 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY General physiology and biophysics Pub Date : 2023-03-01 DOI:10.4149/gpb_2023001
Alzbeta Idunkova, Lubica Lacinova, Lucia Dubiel-Hoppanova
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引用次数: 2

摘要

重度抑郁症是一种非常常见的严重精神疾病,在人群中的患病率越来越高。其病理包括脑各区域的生化、形态和电生理变化。尽管经过几十年的广泛研究,抑郁症的病理生理学仍然没有得到充分的了解。当抑郁症发生在怀孕前或怀孕期间时,它可能对围产期和/或产后大脑发育产生不利影响,影响后代的行为。海马是认知和记忆的中枢,在抑郁症的病理过程中起着重要的作用。在这里,我们回顾了在各种动物模型中发现的第一代和第二代抑郁症引起的形态学、生化和电信号的变化。
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Stress, depression, and hippocampus: from biochemistry to electrophysiology.

Major depressive disorder is a very common serious mental illness with increasing prevalence in the population. Its pathology includes biochemical, morphological, and electrophysiological changes in various brain areas. In spite of decades of extensive research pathophysiology of depression is still not sufficiently understood. When depression occurs just before or during pregnancy, it may have a detrimental effect on perinatal and/or postnatal brain development, affecting the offspring's behavior. An important role in the pathology of depression is the hippocampus as a center for cognition and memory. Here we review changes in morphology, biochemical, and electrical signaling caused by depression in first and second generation identified in various animal models.

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来源期刊
General physiology and biophysics
General physiology and biophysics 生物-生化与分子生物学
CiteScore
2.70
自引率
0.00%
发文量
42
审稿时长
6-12 weeks
期刊介绍: General Physiology and Biophysics is devoted to the publication of original research papers concerned with general physiology, biophysics and biochemistry at the cellular and molecular level and is published quarterly by the Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences.
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