(2S，5S，6Z)-2,5-环氧多聚糖-6-烯-21-乙烯酸，海绵体新脂肪酸

Natural products chemistry & research Pub Date : 2018-01-01 DOI:10.4172/2329-6836.1000336

P. Campos, E. Pichon, B. Illien, P. Clerc, C. Moriou, N. Voogd, C. Hellio, R. Trépos, M. Frédérich, A. Al‐Mourabit, A. Gauvin-Bialecki

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引用次数: 3

摘要

海洋海绵被认为是新的海洋天然产品的丰富来源。本研究对采自马约特岛的海绵状海绵(Haliclona fascigera)的CH2Cl2-MeOH(1:1)提取物进行了化学研究，发现了一种新的不常见的乙炔和四氢呋喃脂肪酸(2S*，5S*，6Z)- 2,5epoxydocosan6 -en-21-ynoic酸(1)。通过HRESIMS数据、IR、1D和2D NMR对其平面结构进行了表征。化合物1的相对构型由密度泛函理论(DFT)计算推导，该计算采用最近发表的DP4+概率拟合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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(2S*,5S*,6Z)-2,5-Epoxydocosan-6-en-21-ynoic Acid, New Fatty Acid from the Marine Sponge Haliclona fascigera

Marine sponges are recognized as a rich source of new marine natural products. In this study, chemical investigation of the CH2Cl2-MeOH (1:1) extract from the marine sponge Haliclona fascigera collected in Mayotte was carried out and highlighted a new unusual acetylenic and tetrahydrofuranic fatty acid, (2S*,5S*,6Z)-2,5epoxydocosan-6-en-21-ynoic acid (1). Its planar structure was elucidated by HRESIMS data, IR, 1D and 2D NMR spectra. The relative configuration of compound 1 was deduced from density functional theory (DFT) computational calculations fitted using the recently published DP4+ probability.

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Natural products chemistry & research

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