Kartika Prabasari, Nia Kurnianingsih, N. Kurniawan
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引用次数: 0
摘要
马来亚金甲蛇毒的抗蛇毒血清在印度尼西亚还没有得到，导致许多致命的蛇咬伤病例。需要探索利用药用植物的替代治疗方法。本研究探讨了药用植物天然活性化合物作为毒毒素α - δ蛋白抑制剂的潜力。采用的方法是利用SWISS-MODEL预测的班加罗毒素念珠菌α - δ蛋白的三维结构。使用backpack Family Database和PubChem进行生物活性化合物的数据挖掘。
In silico Exploration of Bioactive Compounds from Withania somnifera as Inhibitor for Alpha Delta Bungarotoxin of Bungarus candidus Venom
The antivenom for Malayan krait (Bungarus candidus) venom has not yet been available in Indonesia, leading to many fatal snakebite cases. Alternative treatment approaches using medicinal plants are needed to be explored. This study investigated the potential of medicinal plants natural bioactive compounds as toxic alpha-delta protein bungarotoxin inhibitor in B. candidus venom. The approach taken is using the 3D structure of the alpha-delta protein of bungarotoxin B. candidus predicted by SWISS-MODEL. Knapsack Family Database and PubChem were used for bioactive compounds datamining.
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