{"title":"结肠癌中微生物群与T细胞适应性免疫反应的容许性/保护性相互作用","authors":"Z. Mojtahedi, Somayeh Rezaeifard, Z. Faghih","doi":"10.17795/ACR-43883","DOIUrl":null,"url":null,"abstract":"Colon microbiota, as a complex and diverse population, has been shown to be either proor anti-tumorigenic, depending on its content. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which proor anti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance in microbiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggesting the contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer\",\"authors\":\"Z. Mojtahedi, Somayeh Rezaeifard, Z. Faghih\",\"doi\":\"10.17795/ACR-43883\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Colon microbiota, as a complex and diverse population, has been shown to be either proor anti-tumorigenic, depending on its content. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which proor anti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance in microbiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggesting the contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells.\",\"PeriodicalId\":8370,\"journal\":{\"name\":\"Annals of Colorectal Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Colorectal Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17795/ACR-43883\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Colorectal Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17795/ACR-43883","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer
Colon microbiota, as a complex and diverse population, has been shown to be either proor anti-tumorigenic, depending on its content. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which proor anti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance in microbiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggesting the contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells.
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