四氯化碳致肾毒性实验模型

Mirza Fahad Baig, Muhammad Khalil Ahmad Khan
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摘要

四氯化碳(CCl4)在化学工业中广泛用作溶剂。众所周知,它还具有肝和肾毒性作用。它对健康构成严重威胁。它也是肺、肾、肝、脑等重要器官中毒的主要原因之一。目的:观察四氯化碳(CCl4)对大鼠肾脏的肾毒性。方法:实验在日本大卡拉大学动物学系动物馆进行。目标动物是白化鼠。分为对照组和实验组。用30%稀释的CCl4喂养大鼠,观察其对肾脏的毒性作用,用生理盐水喂养对照组。试验为期12 d。12天后取样或解剖测定血清尿素、肌酐、电解质钠(Na)、钾(K)。解剖大鼠,穿刺心脏取血并收集脏器。结果:尿素、肌酐、电解质、钠(Na)、钾(K)较正常值升高,证实CCl4对白化大鼠的肾毒性作用。所有实验数据均采用SPSS-19进行分析。不同处理之间的显著性水平由LSD在0.05%的概率水平上确定。结论:这些发现强调了CCl4带来的巨大健康风险,并强调了采取预防措施和制定安全法规的必要性。
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Renal Toxicity Induced by Carbon Tetrachloride in Experimental Model
Carbon tetrachloride (CCl4) is largely used as a solvent in chemical industries. It is also well known for hepatic and renal toxic actions. It imposes serious health threats. It is also one of the major causes that is toxic for the vital organs like lungs, kidney, liver, brain, etc. Objective: To check nephrotoxicity of Carbon Tetrachloride (CCl4) on Rat Kidneys. Methods: The experiment was conducted at the animal house of the Department of Zoology, University of Okara. The targeted animal was Albino Rat. Two groups were designed control and experimental groups. The rats were fed with 30% diluted CCl4 to check the toxic effect on the kidneys and normal saline to the control group for comparison. A trial for 12 days was conducted for this purpose. Sampling or dissection was done after 12 days to determine serum Urea, Creatinine, and Electrolytes Sodium (Na), and Potassium (K). Rats were dissected and the heart was punctured to take a blood sample and to collect organs. Results: We observed the increased values of Urea, Creatinine and Electrolytes, Sodium (Na), and Potassium (K) as compared to normal values, which have proved the renal toxicity was induced by CCl4 in Albino Rats. All the experimental data were analyzed by using SPSS-19. The level of significance among the various treatments was determined by LSD at a 0.05% level of probability. Conclusions: These findings underline the substantial health risks that CCl4 poses and emphasize the necessity of putting preventative measures and safety regulations in place.
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