阴道炎病原菌的植物治疗及分离病原菌的分子鉴定

Jannathul Firdous
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引用次数: 0

摘要

女性生殖道感染是重大的公共卫生问题,具有相当大的经济后果。甲硝唑和克林霉素等药物无法完全控制阴道感染的增长,这需要新的治疗策略。据报道,一些草药抗菌药物可以抑制阴道感染的生长。白花布尔哈维亚和印楝都是具有抗菌、抗氧化和抗炎特性的草药。在本研究中,收集了感染患者的阴道液样本,并使用不同的培养基进行培养。采用16S rRNA序列对分离的病原菌进行鉴定。分离鉴定了4种致病菌。检出的病原菌分别为气单胞菌、乳酸菌、金黄色葡萄球菌和肺炎克雷伯菌。对分离的病原菌进行了抗阴道炎活性分析。对金黄色葡萄球菌和洞穴气单胞菌均有最大抑制区。本研究证实白花布尔哈维亚和印楝提取物对阴道病原菌有一定的控制作用,且无副作用
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Vaginitis phyto therapy against vaginal pathogen and molecular identification of isolated vaginal pathogen
Female genital tract infections are major public health problems, with considerable economic consequences. Drugs like metronidazole and clindamycin are unable to control the growth of vaginal infection completely, which requires alternate novel treatment strategies. Some herbal antimicrobial agents are reported to inhibit the growth of vaginal infection. Boerhaavia diffusa andAzadirachta indica are such herbs with antimicrobial, antioxidant and anti-inflammatory properties. In the present study, vaginal fluid samples from infected patients were collected and cultured using different media. Isolated pathogens were identified using 16S rRNA sequence. Four bacterial pathogens were isolated and identified. The pathogens identified were Aeromonas cavia, Lactobacillus, Staphylococcus aureus and Klebsiella pneumomiae. Anti-vaginalis activity of the two herbs were analysed in an isolated pathogen. Maximum zone of inhibition was observed against S. aureus and Aeromonas caviae. The present investigation confirmed that, Boerhaavia diffusa andAzadirachta indica herbal extracts were able to control the vaginal pathogens without any side-effects
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