免疫介导的风湿病的炎症和虚弱:如何解决和评分问题。

IF 8.4 2区 医学 Q1 ALLERGY Clinical Reviews in Allergy & Immunology Pub Date : 2023-04-01 DOI:10.1007/s12016-022-08943-z
Fausto Salaffi, Andrea Di Matteo, Sonia Farah, Marco Di Carlo
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引用次数: 13

摘要

虚弱是风湿病学中的一个新概念,可以帮助识别更有可能出现不良结果的人。骨骼肌减少症和炎症可被视为身体虚弱的生物学基础。虚弱正越来越被广泛接受为衰老的一项指标,并与跌倒、受伤和死亡等负面后果的风险增加有关。“虚弱”指的是一群老年人,尽管他们的合并症、人口结构、性别和年龄相似,但他们似乎比同龄的老年人更贫穷、更脆弱。一些研究表明,炎症通过抑制生长因子、增加分解代谢和破坏体内平衡信号来影响免疫介导的途径、多发病和虚弱。随着年龄的增长,虚弱在社区居民中更为常见,65岁以上的老年人中虚弱的比例为7%至10%,而80多岁的老年人中虚弱的比例为40%。已经验证了不同的参数来识别脆弱性。这些主要涉及两个概念模型:弗里德的身体脆弱表型和洛克伍德的累积缺陷方法。免疫介导的风湿性疾病(imrd),如类风湿关节炎、脊椎关节炎、系统性红斑狼疮、系统性硬化症和血管炎,是发展中国家虚弱的主要原因。本综述的目的是定量综合已发表的关于imrd中虚弱患病率的文献,并总结目前最广泛使用的虚弱筛查工具的相关性和适用性的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Inflammaging and Frailty in Immune-Mediated Rheumatic Diseases: How to Address and Score the Issue.

Frailty is a new concept in rheumatology that can help identify people more likely to have less favorable outcomes. Sarcopenia and inflammaging can be regarded as the biological foundations of physical frailty. Frailty is becoming more widely accepted as an indicator of ageing and is linked to an increased risk of negative outcomes such as falls, injuries, and mortality. Frailty identifies a group of older adults that seem poorer and more fragile than their age-matched counterparts, despite sharing similar comorbidities, demography, sex, and age. Several studies suggest that inflammation affects immune-mediated pathways, multimorbidity, and frailty by inhibiting growth factors, increasing catabolism, and by disrupting homeostatic signaling. Frailty is more common in the community-dwelling population as people get older, ranging from 7 to 10% in those over 65 years up to 40% in those who are octogenarians. Different parameters have been validated to identify frailty. These primarily relate to two conceptual models: Fried's physical frailty phenotype and Rockwood's cumulative deficit method. Immune-mediated rheumatic diseases (IMRDs), such as rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, systemic sclerosis, and vasculitis, are leading causes of frailty in developing countries. The aim of this review was to quantitatively synthesize published literature on the prevalence of frailty in IMRDs and to summarize current evidence on the relevance and applicability of the most widely used frailty screening tools.

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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
期刊最新文献
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