两种简单分光光度法测定盐酸苯肾上腺素的纯态和剂型

Hanan Hameed, Salim Ali
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摘要

建立了两种灵敏、准确、稳定、回收率高的分光光度法测定游离形态盐酸苯肾上腺素和制剂中的盐酸苯肾上腺素。在方法(A)中,苯肾上腺素在氢氧化钠的碱性溶液中被高锰酸钾氧化,在波长610 nm处测量得到的锰酸盐(mno42 -)的蓝绿色,该波长与苯肾上腺素- hcl的量成线性比例。方法(B),在盐酸溶液的酸性介质中使用过量的n -溴代琥珀酰亚胺氧化盐酸苯甲素,用剩余(未反应的)n -溴代琥珀酰亚胺漂白靛蓝胭脂红染料,在波长610 nm处测量剩余染料的蓝色吸光度。它与盐酸苯肾上腺素的浓度成正比。方法(A)和(B)的摩尔吸收系数分别为1.5722×10 4和5.5191×10 4 L/mol。厘米,分别。两种方法的Beer’s定律在0.2 ~ 8.0µg/mL(方法A)和0.2 ~ 3.5µg/mL(方法B)的浓度范围内均呈线性关系,方法A和方法B的相对标准偏差值分别优于0.0286和0.0114。应用这两种方法对盐酸苯肾上腺素注射液和滴剂进行了评价。
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Development of Two Simple Spectrophotometric Methods to Assay Phenylephrine-HCl as Pure Form And in Its Drug Forms
This work includes the development of two spectrophotometric methods which are sensitive, accurate, stable, and has good recovery for the determination of phenylephrine-HCl as free form and in the pharmaceutical preparations. In the method (A), phenylephrine is oxidized by potassium permanganate in a basic solution of sodium hydroxide and the bluish-green color of the resulting manganate (MnO 42- ) is measured at wavelength 610 nm, which is linearly proportional to the amount of phenylephrine-HCl. Method (B), is involved the oxidation of phenylephrine-HCl by using an excess amount of N-bromosuccinimide in an acidic medium of hydrochloric acid solution, the remaining (unreacted) amount of N-bromosuccinimide is used to bleach indigo carmine dye and the absorbance of the blue color of the remaining dye is measured at the wavelength of 610 nm. which is directly proportional to the concentration of phenylephrine-HCl. The molar absorptivity coefficients of methods (A) and (B) are estimated and equal to 1.5722×10 4 and 5.5191×10 4 L/mol.cm, respectively. Beer’s law of the both methods are linear in the concentration ranges 0.2–8.0 µg/mL (method A) and 0.2–3.5 µg/mL (method B). The relative standard deviation values of methods (A) and (B) are also found to be better than 0.0286 and 0.0114, respectively. The two proposed methods are applied to estimate phenylephrine-HCl in injection and drop.
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