Murad I.H Helaleh , T Korenaga , Eyad S.M Abu-Nameh , Rasheed M.A.Q Jamhour
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引用次数: 5
摘要
本文介绍了一种新的分析纯对乙酰氨基酚及其制剂的简单、准确的动力学方法。将动力学参数成功地应用于对乙酰氨基酚在碱性介质中与过硫酸盐反应的测定。分光光度测量已在315 nm记录，并发现在5-30 ppm的浓度范围内有效。摩尔吸收率等于6.55×103 l mol−1 cm−1。对不同物质混合物中扑热息痛的含量进行了不预先分离的分析。研究了该方法的精密度和准确度以及外来物质的影响，并与参考方法进行了比较。
Assay of paracetamol by oxidation with peroxydisulphate
A new simple and accurate kinetic method for the analysis of paracetamol in pure form and formulations is described. The kinetics parameters have been applied successfully in determining paracetamol when it reacts with persulfate in alkaline medium. The spectrophotometric measurements have been recorded at 315 nm and found to be valid over the concentration range of 5–30 ppm. The molar absorptivity is equal to 6.55×103 l mol−1 cm−1. The analysis of paracetamol content in mixture of different substances has been carried out without prior separation. The precision and accuracy of the method and the effect of foreign substances have been studied and the results obtained were compared with reference method.
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