Canine Blood Sugar and Lactic Acid Responses to Adrenergic Amines after Ganglion Block*

Since preliminary studies indicated that a ganglionic block before infusions of some adrenergic amines resulted in an increased production of blood lactic acid and blood sugar, it was postulated that this might be due to an interruption of Cori's cycle. This experiment shows that there is a significant increase in lactic acid produced by two of the drugs after blocking and an indication that two others also have this effect. The results on blood sugar were not significant. Evidence is presented here that the conversion of lactic acid to glycogen in the liver is blocked or inhibited by use of the ganglion blocking agent, mecamylamine, accounting for an accumulation of blood lactic acid under the conditions of the experiment.