人工智能辅助制造用于药物输送的3D, 4D和5D打印配方或设备。

IF 2.8 4区 医学 Q2 PHARMACOLOGY & PHARMACY Current drug delivery Pub Date : 2023-01-01 DOI:10.2174/1567201820666221207140956
Kiran Singh Sharma
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引用次数: 3

摘要

5D和4D打印是3D打印类的高级版本,是最具革命性和强大的制造方法之一,用于使用精确的增材制造技术制备创新结构和固体物质。它抓住了一个人的想象力,它具有生产灵活设计和制造创新产品的潜力,具有高复杂性和速度。这项技术在人工智能(AI)的帮助下,有助于实时感知,适应变化,并预测打印状态。3D打印的工作原理是采用先进的材料,利用计算机辅助设计,在人工智能控制下进行断层扫描,根据文件的性质沉积打印材料,通常为STL格式,但打印需要时间。这一缺点可以通过4D打印来克服,其中智能材料与时间结合为第四维。这种技术具有自我修复和自组装的特性,可以节省大约80%的时间。一些打印材料对温度、湿度、光线和其他参数很敏感,因此它们可以对刺激做出反应,但是不能打印具有曲面的复杂形状的一个限制可以通过利用5D打印来克服,其中增材制造是通过旋转挤出机头和旋转打印床来在5个不同的轴上打印的。本文综述了这些人工智能干扰技术在医学和药学领域的前景,以及其有效和高效的生产所要求的设计精度。
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Artificial Intelligence Assisted Fabrication of 3D, 4D and 5D Printed Formulations or Devices for Drug Delivery.

5D & 4D printings are an advanced version of 3D printing class and are one of the most revolutionary and powerful fabrication methods used for preparing innovative structures and solid substances using precise additive manufacturing technology. It captures the imagination of one with its potential to produce flexible designing and fabrication of innovative products with high complexity and speed. This technology with the assistance of AI (Artificial Intelligence) facilitates real-time sensing, adapting to change, and predicting the state of printing. 3D printing works by employing advanced materials utilizing a computer aided design with tomography scan under AI control which deposits printing material in accordance with the nature of a file usually in STL format, but it requires time for printing. This shortcoming can be overcome by 4D printing where smart materials are incorporated with time as 4th dimension. This technique has self-repair and self-assembly properties that will save around 80% of time. Some printed materials are made sensitive to temperature, humidity, light, and other parameters so that they can respond to stimulus, but it's one limitation of not being able to print complex shapes having curved surfaces can be overcome by utilising 5D printing where additive manufacturing is done by rotation of extruder head and rotation of print bed to print in 5 different axes. This review evaluates the prospective of these techniques with AI interference in medicine and pharmacy, with its effective and efficient production for the required design precision.

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来源期刊
Current drug delivery
Current drug delivery PHARMACOLOGY & PHARMACY-
CiteScore
5.10
自引率
4.20%
发文量
170
期刊介绍: Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.
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