用n -溴代琥珀酰亚胺温和有效地催化黄酮二酮的α-溴化反应

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-01-01 DOI:10.1080/10426507.2021.1987432

R. Shashi , Noor Shahina Begum

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引用次数: 0

摘要

本文研究了在对甲苯磺酸(PTSA)存在下，利用n -溴琥珀酰亚胺(NBS)合成2,7-二溴杂蒽二酮的高效方法。在温和的反应条件下，NBS和PTSA在氯仿中的组合是一种高效的选择性α-溴化体系。该方法的主要优点是反应时间短，反应条件温和，易于操作，收率高。所有合成的化合物都用光谱技术进行了表征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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α-Bromination of xanthenediones: A mild and efficient approach using N-bromosuccinimide

The present work deals with a practically efficient protocol designed for the synthesis of 2,7-dibromoxanthenediones using N-bromosuccinimide (NBS) in the presence of p-toluene sulfonic acid (PTSA). A combination of NBS and PTSA in chloroform is an efficient system for selective α-bromination of xanthenediones under mild reaction conditions. The main advantage of this method is short reaction duration, mild reaction conditions, easy work up and in addition the method provides excellent yields. All the compounds synthesized were characterized by spectroscopic techniques.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.