双位点吸附剂对映体竞争吸附等温线的测定

Bee-Gim Lim, Chi-Bun Ching, Reginald B.H. Tan
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引用次数: 27

摘要

采用浓度脉冲色谱法测定吡喹酮对映体在微晶三醋酸纤维素上的竞争吸附等温线。发现一个由非选择性线性项和选择性一阶改进朗缪尔项组成的模型能很好地拟合数据。假设这种手性固定相由两种类型的结合位点组成:一种负责手性、选择性相互作用,另一种负责对映体与固定相的非手性、非选择性相互作用。与非选择性位点相比,选择性位点容易饱和,这是实验观察到的在高对映体浓度下分离效率较低的原因。
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Determination of competitive adsorption isotherms of enantiomers on a dual-site adsorbent

The competitive adsorption isotherms of praziquantel enantiomers on microcrystalline cellulose triacetate were determined by concentration pulse chromatography. A model comprising a non-selective linear term and a selective first order improved Langmuir term was found to fit the data excellently. It is postulated that this chiral stationary phase consists of two types of binding sites: one responsible for the chiral, selective interactions and one responsible for the achiral, non-selective interactions of the enantiomers with the stationary phase. The selective sites are easily saturated compared to the non-selective sites, accounting for the experimental observation of lower separation efficiency at higher enantiomer concentrations.

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