新型固定化β-环糊精聚合物对非共轭胆红素的吸附

Xiao-Bin Zhao, Bing-Lin He, (Ping-Lum Ho)
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引用次数: 8

摘要

将β-环糊精(β-CyD)固定在具有不同官能团CH2Cl、SO2Cl和SO2Cl的交联聚苯乙烯载体上,合成了3种新型的β-环糊精(β-CyD)聚合物。生物医学吸附剂,测试了它们对非共轭胆红素(BR)的去除能力。结果表明,β-CyD对BR的吸附能力是由其与BR的包合作用决定的。吸附时间、吸附介质的pH值、BR和白蛋白的浓度、载体上固定β-CyD的量以及交联程度等因素都可能影响吸附量。并对吸附机理进行了研究。
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Sorption of unconjugated bilirubin by means of novel immobilized β-cyclodextrin polymers

Three kinds of novel β-cyclodextrin (β-CyD) polymers were synthesized by immobilization of β-CyD onto the crosslinked polystyrene supports with different functional groups such as CH2Cl, SO2Cl and

. biomedical adsorbents, they were tested for their removal capacity of unconjugated bilirubin (BR). The results indicate that the adsorption capacity for BR is due to the inclusion interaction between β-CyD and BR. Many factors such as the adsorption time, the pH value of the adsorption medium, the concentrations of BR and albumin, the amount of β-CyD immobilized on the supports and the degree of crosslinking may affect the adsorption capacity. The adsorption mechanism was also studied.

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