COVID-19中的自然杀伤细胞:从感染到疫苗接种和治疗。

IF 2.1 4区医学 Q3 VIROLOGY Future Virology Pub Date : 2023-02-01 DOI:10.2217/fvl-2022-0040

Alireza Zafarani, Mohammad Hossein Razizadeh, Salar Pashangzadeh, Mohammad Reza Amirzargar, Mahsa Taghavi-Farahabadi, Mohammad Mahmoudi

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引用次数: 3

摘要

自然杀伤细胞(NK)是最重要的先天免疫成员之一，是第一个对抗感染细胞的细胞。在COVID-19患者中，这些细胞的功能受损，它们无法阻止疾病的传播或破坏受感染的细胞。很少有研究评估COVID-19疫苗对NK细胞的影响，尽管已经证明DNA疫苗和BNT162b2可以影响NK细胞的反应。本文就SARS-CoV-2在感染过程中对NK细胞的影响、疫苗接种对NK细胞的影响以及NK细胞为基础的治疗方法进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Natural killer cells in COVID-19: from infection, to vaccination and therapy.

Natural killer (NK) cells are among the most important innate immunity members, which are the first cells that fight against infected cells. The function of these cells is impaired in patients with COVID-19 and they are not able to prevent the spread of the disease or destroy the infected cells. Few studies have evaluated the effects of COVID-19 vaccines on NK cells, though it has been demonstrated that DNA vaccines and BNT162b2 can affect NK cell response. In the present paper, the effects of SARS-CoV-2 on the NK cells during infection, the effect of vaccination on NK cells, and the NK cell-based therapies were reviewed.

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.