大重链缺失患者IgG3抗体对COVID-19疫苗接种的应答

Sandeep Sarkaria, Zachary Hostoffer, Meghan Callahan, John Venglarick, Robert Hostoffer
{"title":"大重链缺失患者IgG3抗体对COVID-19疫苗接种的应答","authors":"Sandeep Sarkaria,&nbsp;Zachary Hostoffer,&nbsp;Meghan Callahan,&nbsp;John Venglarick,&nbsp;Robert Hostoffer","doi":"10.1177/27534030231156206","DOIUrl":null,"url":null,"abstract":"<p><p>Vaccinations for pathogenic organisms have been utilized for decades in both the protection and diagnosis of immunodeficiency patients. Some of these immunodeficient patients may not create an adequate response to vaccination, although some who have significant aberrancies in their immune system may surprisingly create antibodies to immunizations. We present a patient with a large Ig heavy chain deletion (severe deficiency of serum IgG1, IgG2, IgG4, and IgA1) that showed a considerable response (presumably through IgG3) after the Pfizer BioNTech COVID-19 vaccination. This finding in this unique immunodeficient patient warrants further research into alternate antibody response pathways against COVID-19.</p>","PeriodicalId":75217,"journal":{"name":"Therapeutic advances in allergy and rhinology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/5d/10.1177_27534030231156206.PMC10035523.pdf","citationCount":"0","resultStr":"{\"title\":\"IgG3 Antibody Response to COVID-19 Vaccination in a Patient With a Large Heavy Chain Deletion.\",\"authors\":\"Sandeep Sarkaria,&nbsp;Zachary Hostoffer,&nbsp;Meghan Callahan,&nbsp;John Venglarick,&nbsp;Robert Hostoffer\",\"doi\":\"10.1177/27534030231156206\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Vaccinations for pathogenic organisms have been utilized for decades in both the protection and diagnosis of immunodeficiency patients. Some of these immunodeficient patients may not create an adequate response to vaccination, although some who have significant aberrancies in their immune system may surprisingly create antibodies to immunizations. We present a patient with a large Ig heavy chain deletion (severe deficiency of serum IgG1, IgG2, IgG4, and IgA1) that showed a considerable response (presumably through IgG3) after the Pfizer BioNTech COVID-19 vaccination. This finding in this unique immunodeficient patient warrants further research into alternate antibody response pathways against COVID-19.</p>\",\"PeriodicalId\":75217,\"journal\":{\"name\":\"Therapeutic advances in allergy and rhinology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/5d/10.1177_27534030231156206.PMC10035523.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapeutic advances in allergy and rhinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/27534030231156206\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"0\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic advances in allergy and rhinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/27534030231156206","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"0","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

几十年来,在免疫缺陷患者的保护和诊断中,已经使用了病原生物疫苗。其中一些免疫缺陷患者可能不会对疫苗产生足够的反应,尽管一些免疫系统有明显异常的患者可能会令人惊讶地产生免疫抗体。我们报告了一名大Ig重链缺失(血清IgG1、IgG2、IgG4和IgA1严重缺乏)的患者,在辉瑞BioNTech COVID-19疫苗接种后显示出相当大的反应(可能是通过IgG3)。这一独特的免疫缺陷患者的发现值得进一步研究针对COVID-19的替代抗体反应途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
IgG3 Antibody Response to COVID-19 Vaccination in a Patient With a Large Heavy Chain Deletion.

Vaccinations for pathogenic organisms have been utilized for decades in both the protection and diagnosis of immunodeficiency patients. Some of these immunodeficient patients may not create an adequate response to vaccination, although some who have significant aberrancies in their immune system may surprisingly create antibodies to immunizations. We present a patient with a large Ig heavy chain deletion (severe deficiency of serum IgG1, IgG2, IgG4, and IgA1) that showed a considerable response (presumably through IgG3) after the Pfizer BioNTech COVID-19 vaccination. This finding in this unique immunodeficient patient warrants further research into alternate antibody response pathways against COVID-19.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Outcomes of Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyposis and Risk Factors of Recurrence in a Tertiary Care Teaching Hospital. Acute Vision Loss in Patients With Allergic Fungal Rhinosinusitis: A Case Series. Central Compartment Atopic Disease and Its Surgical Outcomes: Olfactory Changes and Technical Notes. Epinephrine Administered in Anaphylaxis: The Evolution of 0.3 mg Dosage. IgM Deficiency Associated With Connexin Mutation in an 18-Year-old Male.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1