大重链缺失患者IgG3抗体对COVID-19疫苗接种的应答

Sandeep Sarkaria, Zachary Hostoffer, Meghan Callahan, John Venglarick, Robert Hostoffer
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摘要

几十年来,在免疫缺陷患者的保护和诊断中,已经使用了病原生物疫苗。其中一些免疫缺陷患者可能不会对疫苗产生足够的反应,尽管一些免疫系统有明显异常的患者可能会令人惊讶地产生免疫抗体。我们报告了一名大Ig重链缺失(血清IgG1、IgG2、IgG4和IgA1严重缺乏)的患者,在辉瑞BioNTech COVID-19疫苗接种后显示出相当大的反应(可能是通过IgG3)。这一独特的免疫缺陷患者的发现值得进一步研究针对COVID-19的替代抗体反应途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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IgG3 Antibody Response to COVID-19 Vaccination in a Patient With a Large Heavy Chain Deletion.

Vaccinations for pathogenic organisms have been utilized for decades in both the protection and diagnosis of immunodeficiency patients. Some of these immunodeficient patients may not create an adequate response to vaccination, although some who have significant aberrancies in their immune system may surprisingly create antibodies to immunizations. We present a patient with a large Ig heavy chain deletion (severe deficiency of serum IgG1, IgG2, IgG4, and IgA1) that showed a considerable response (presumably through IgG3) after the Pfizer BioNTech COVID-19 vaccination. This finding in this unique immunodeficient patient warrants further research into alternate antibody response pathways against COVID-19.

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