最好的GVHD预防方法:或者至少朝着找到它的方向前进

IF 2.2 4区 医学 Q3 HEMATOLOGY Best Practice & Research Clinical Haematology Pub Date : 2023-10-20 DOI:10.1016/j.beha.2023.101520
Daniel Weisdorf , Najla El Jurdi , Shernan G. Holtan
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引用次数: 0

摘要

同种异体造血细胞移植后预防GVHD的选择最好是通过了解GVHD的病理生理机制来选择。限制T细胞活化、扩增和随后的组织损伤的干预措施都可以用于设计成功的GVHD预防策略,消耗、耐受或钝化T细胞或宿主抗原呈递细胞(apc),阻断共刺激或更广泛地抑制炎症都已被使用。不使用调节性T细胞(Tregs)的干预措施可以预防GVHD,促进可控的同种异体反应,并且不会降低随后的复发风险。移植物操作和药物干预都有可能限制GVHD的发病率,同时允许免疫能力预防感染或复发。
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The best GVHD prophylaxis: Or at least progress towards finding it

Options for GVHD prophylaxis after allogeneic hematopoietic cell transplantation can best be chosen by understanding the pathophysiology of GVHD. Interventions to limit T cell activation, expansion and subsequent tissue injury can each be utilized in designing successful GVHD prevention strategies Depleting, tolerizing or blunting T cells or host antigen presenting cells (APCs), blocking co-stimulation or more broadly suppressing inflammation have all been used. Interventions which spare regulatory T cells (Tregs) may prevent GVHD and facilitate controlled allo-responses and not compromise subsequent relapse risks. Graft manipulations and pharmacologic interventions each have potential to limit the morbidity of GVHD while permitting the immunocompetence to prevent infection or relapse.

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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.
期刊最新文献
Erratum to “Special issue 37.2 and 37.3 Genetics and Function of HLA and immune-related genes in transplantation and cellular immunotherapy” [Best Pract Res Clin Haematol (2024) 101588] Editorial Board From clones to immunopeptidomes: New developments in the characterization of permissive HLA-DP mismatches in hematopoietic cell transplantation Relevance of donor-specific HLA antibodies in hematopoietic cell transplantation HLA structure and function in hematopoietic-cell transplantation
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