Olegi N. Kukaliia MD , Sergei V. Ageev MSc , Andrey V. Petrov MSc , Olga V. Kirik PhD , Dmitrii E. Korzhevskii PhD , Anatolii A. Meshcheriakov PhD , Anastasia A. Jakovleva PhD , Liudmila S. Poliakova PhD , Tatiana A. Novikova PhD , Maria E. Kolpakova PhD , Timur D. Vlasov DSc , Oleg E. Molchanov DSc , Dmitriy N. Maistrenko DSc , Igor V. Murin DSc , Vladimir V. Sharoyko DSc , Konstantin N. Semenov DSc
{"title":"含l -精氨酸的C60加合物是治疗缺血性脑卒中的一种有前景的纳米材料","authors":"Olegi N. Kukaliia MD , Sergei V. Ageev MSc , Andrey V. Petrov MSc , Olga V. Kirik PhD , Dmitrii E. Korzhevskii PhD , Anatolii A. Meshcheriakov PhD , Anastasia A. Jakovleva PhD , Liudmila S. Poliakova PhD , Tatiana A. Novikova PhD , Maria E. Kolpakova PhD , Timur D. Vlasov DSc , Oleg E. Molchanov DSc , Dmitriy N. Maistrenko DSc , Igor V. Murin DSc , Vladimir V. Sharoyko DSc , Konstantin N. Semenov DSc","doi":"10.1016/j.nano.2023.102698","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span>The work aimed to investigate the biocompatibility and </span>biological activity of the water-soluble </span>fullerene adduct C</span><sub>60</sub><span><span>-Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of application of water-soluble fullerene adducts in the creation of </span>neuroprotectors. It has been suggested that a putative mechanism of the protective action of the C</span><sub>60</sub><span>-Arg adduct is associated with its antioxidant properties, the ability to penetrate the blood-brain barrier, and release nitrogen monoxide as a result of the catabolism of L-arginine residues, which promote vascular relaxation. The action of the C</span><sub>60</sub><span><span>-Arg adduct was compared with the action of such an antioxidant as Edaravone, which is approved in </span>Japan<span> for the treatment of ischemic and haemorrhagic strokes.</span></span></p></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"C60 adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke\",\"authors\":\"Olegi N. Kukaliia MD , Sergei V. Ageev MSc , Andrey V. Petrov MSc , Olga V. Kirik PhD , Dmitrii E. Korzhevskii PhD , Anatolii A. Meshcheriakov PhD , Anastasia A. Jakovleva PhD , Liudmila S. Poliakova PhD , Tatiana A. Novikova PhD , Maria E. Kolpakova PhD , Timur D. Vlasov DSc , Oleg E. Molchanov DSc , Dmitriy N. Maistrenko DSc , Igor V. Murin DSc , Vladimir V. Sharoyko DSc , Konstantin N. Semenov DSc\",\"doi\":\"10.1016/j.nano.2023.102698\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span>The work aimed to investigate the biocompatibility and </span>biological activity of the water-soluble </span>fullerene adduct C</span><sub>60</sub><span><span>-Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of application of water-soluble fullerene adducts in the creation of </span>neuroprotectors. It has been suggested that a putative mechanism of the protective action of the C</span><sub>60</sub><span>-Arg adduct is associated with its antioxidant properties, the ability to penetrate the blood-brain barrier, and release nitrogen monoxide as a result of the catabolism of L-arginine residues, which promote vascular relaxation. The action of the C</span><sub>60</sub><span><span>-Arg adduct was compared with the action of such an antioxidant as Edaravone, which is approved in </span>Japan<span> for the treatment of ischemic and haemorrhagic strokes.</span></span></p></div>\",\"PeriodicalId\":19050,\"journal\":{\"name\":\"Nanomedicine : nanotechnology, biology, and medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomedicine : nanotechnology, biology, and medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1549963423000497\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine : nanotechnology, biology, and medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1549963423000497","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
C60 adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke
The work aimed to investigate the biocompatibility and biological activity of the water-soluble fullerene adduct C60-Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of application of water-soluble fullerene adducts in the creation of neuroprotectors. It has been suggested that a putative mechanism of the protective action of the C60-Arg adduct is associated with its antioxidant properties, the ability to penetrate the blood-brain barrier, and release nitrogen monoxide as a result of the catabolism of L-arginine residues, which promote vascular relaxation. The action of the C60-Arg adduct was compared with the action of such an antioxidant as Edaravone, which is approved in Japan for the treatment of ischemic and haemorrhagic strokes.
期刊介绍：
The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine.
Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
